Molecular-length and chiral discriminations by β-structural poly(L-alanine) on silica

Atsuomi Shundo, Toshihiko Sakurai, Makoto Takafuji, Shoji Nagaoka, Hirotaka Ihara

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Poly(l-alanine)-grafted porous silica (Sil-Ala22) was prepared by polymerization of N-carboxyanhydride of l-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala22. Sil-Ala22 showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple π-π interaction with the carbonyl groups one dimensionally-aligned on the rigid β-form structure in the peptide main chain. Chiral separation with Sil-Ala22 was also described.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of Chromatography A
Volume1073
Issue number1-2
DOIs
Publication statusPublished - May 6 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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