Molecular-length and chiral discriminations by β-structural poly(L-alanine) on silica

Atsuomi Shundo, Toshihiko Sakurai, Makoto Takafuji, Shoji Nagaoka, Hirotaka Ihara

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Poly(l-alanine)-grafted porous silica (Sil-Ala 22 ) was prepared by polymerization of N-carboxyanhydride of l-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala 22 . Sil-Ala 22 showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple π-π interaction with the carbonyl groups one dimensionally-aligned on the rigid β-form structure in the peptide main chain. Chiral separation with Sil-Ala 22 was also described.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of Chromatography A
Volume1073
Issue number1-2
DOIs
Publication statusPublished - May 6 2005
Externally publishedYes

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Silicon Dioxide
Alanine
Liquid chromatography
Liquid Chromatography
Polymerization
Peptides
Molecules
polyalanine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

Molecular-length and chiral discriminations by β-structural poly(L-alanine) on silica. / Shundo, Atsuomi; Sakurai, Toshihiko; Takafuji, Makoto; Nagaoka, Shoji; Ihara, Hirotaka.

In: Journal of Chromatography A, Vol. 1073, No. 1-2, 06.05.2005, p. 169-174.

Research output: Contribution to journalArticle

Shundo, Atsuomi ; Sakurai, Toshihiko ; Takafuji, Makoto ; Nagaoka, Shoji ; Ihara, Hirotaka. / Molecular-length and chiral discriminations by β-structural poly(L-alanine) on silica. In: Journal of Chromatography A. 2005 ; Vol. 1073, No. 1-2. pp. 169-174.
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