Abstract
Accumulating clinical data indicates that insulin resistance and diabetes mellitus (DM) are major risk factors for Alzheimer’s disease (AD); however, the exact mechanisms on how insulin resistance and DM act as risk factors for AD remain unclear. Recent progress in gene expression profiling of AD brains revealed that brain insulin production and insulin signaling are significantly impaired, indicating that AD brain exhibits a feature of brain diabetes with depletion of brain insulin, which causes mitochondrial dysfunction with increased oxidative stress, thereby increasing sensitivity to peripheral diabetes. Such diabetic condition in early stage of AD brain can be exacerbated by peripheral diabetes, namely, through hyperglycemia, hyperinsulinemia, or impaired insulin response. In this chapter, I reviewed mitochondrial dysfunction and oxidative stress in AD brain and discussed how those events are involved in AD pathogenesis.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 27-44 |
| Number of pages | 18 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1128 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. / Nakabeppu, Yusaku.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 27-44 (Advances in Experimental Medicine and Biology; Vol. 1128).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain
AU - Nakabeppu, Yusaku
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Accumulating clinical data indicates that insulin resistance and diabetes mellitus (DM) are major risk factors for Alzheimer’s disease (AD); however, the exact mechanisms on how insulin resistance and DM act as risk factors for AD remain unclear. Recent progress in gene expression profiling of AD brains revealed that brain insulin production and insulin signaling are significantly impaired, indicating that AD brain exhibits a feature of brain diabetes with depletion of brain insulin, which causes mitochondrial dysfunction with increased oxidative stress, thereby increasing sensitivity to peripheral diabetes. Such diabetic condition in early stage of AD brain can be exacerbated by peripheral diabetes, namely, through hyperglycemia, hyperinsulinemia, or impaired insulin response. In this chapter, I reviewed mitochondrial dysfunction and oxidative stress in AD brain and discussed how those events are involved in AD pathogenesis.
AB - Accumulating clinical data indicates that insulin resistance and diabetes mellitus (DM) are major risk factors for Alzheimer’s disease (AD); however, the exact mechanisms on how insulin resistance and DM act as risk factors for AD remain unclear. Recent progress in gene expression profiling of AD brains revealed that brain insulin production and insulin signaling are significantly impaired, indicating that AD brain exhibits a feature of brain diabetes with depletion of brain insulin, which causes mitochondrial dysfunction with increased oxidative stress, thereby increasing sensitivity to peripheral diabetes. Such diabetic condition in early stage of AD brain can be exacerbated by peripheral diabetes, namely, through hyperglycemia, hyperinsulinemia, or impaired insulin response. In this chapter, I reviewed mitochondrial dysfunction and oxidative stress in AD brain and discussed how those events are involved in AD pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=85065663324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065663324&partnerID=8YFLogxK
U2 - 10.1007/978-981-13-3540-2_3
DO - 10.1007/978-981-13-3540-2_3
M3 - Chapter
C2 - 31062324
AN - SCOPUS:85065663324
T3 - Advances in Experimental Medicine and Biology
SP - 27
EP - 44
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -