TY - JOUR
T1 - Molecular recognition and self-organization in life phenomena studied by a statistical mechanics of molecular liquids, the rism/3d-rism theory
AU - Sugita, Masatake
AU - Onishi, Itaru
AU - Irisa, Masayuki
AU - Yoshida, Norio
AU - Hirata, Fumio
N1 - Funding Information:
Acknowledgments: F.H. was a fellow in the Toyota Physical and Chemical Research Institute from 1 April 2016 to 31 March 2020. The studies related to the structural fluctuation of protein, reviewed in this paper, were carried out mainly during the stay at the institute. He is grateful to the financial support from the institute. Writing this paper received no external funding.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/2
Y1 - 2021/1/2
N2 - There are two molecular processes that are essential for living bodies to maintain their life: the molecular recognition, and the self-organization or self-assembly. Binding of a substrate by an enzyme is an example of the molecular recognition, while the protein folding is a good example of the self-organization process. The two processes are further governed by the other two physicochemical processes: solvation and the structural fluctuation. In the present article, the studies concerning the two molecular processes carried out by Hirata and his coworkers, based on the statistical mechanics of molecular liquids or the RISM/3D-RISM theory, are reviewed.
AB - There are two molecular processes that are essential for living bodies to maintain their life: the molecular recognition, and the self-organization or self-assembly. Binding of a substrate by an enzyme is an example of the molecular recognition, while the protein folding is a good example of the self-organization process. The two processes are further governed by the other two physicochemical processes: solvation and the structural fluctuation. In the present article, the studies concerning the two molecular processes carried out by Hirata and his coworkers, based on the statistical mechanics of molecular liquids or the RISM/3D-RISM theory, are reviewed.
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U2 - 10.3390/molecules26020271
DO - 10.3390/molecules26020271
M3 - Article
C2 - 33430461
AN - SCOPUS:85099897715
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 2
M1 - 271
ER -