Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip

Ibuki Yoshimura, Yoshifumi Miyahara, Noriyuki Kasagi, Hiroki Yamane, Akio Ojida, Itaru Hamachi

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

This communication describes a new molecular recognition chip using a semi-wet microenvironment provided by a self-assembled hydrogel. On the basis of the evidence that the molecular recognition capability of artificial chemosensors are practically retained even in the hydrogel compared to those in aqueous solution, we miniaturized the functionalized hydrogel to produce an unprecedented molecular recognition chip. We believe that the present noncovalent immobilization method is generally applicable to many chemosensors, which leads to a unique semi-wet sensor chip suitable to convenient and high-throughput assay to plural analytes.

Original languageEnglish
Pages (from-to)12204-12205
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number39
DOIs
Publication statusPublished - Oct 6 2004

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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