Molecular transporter between polymer platforms: Highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports

Masataka Fumoto, Hiroshi Hinou, Takahiko Matsushita, Masaki Kurogochi, Takashi Ohta, Takaomi Ito, Kuriko Yamada, Akio Takimoto, Hirosato Kondo, Toshiyuki Inazu, Shin Ichiro Nishimura

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

(Figure Presented) The molecule standing at platform one ...: Rapid glycopeptide synthesis is achieved with a heterobifunctional "molecular transporter" (see scheme), which interfaces two types of polymer platforms for combined chemical and enzymatic synthesis. This linker allows both chemoselective blotting and photoselective cleavage of the glycopeptides. Red: sugar residues; green: amino acid residues.

Original languageEnglish
Pages (from-to)2534-2537
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number17
DOIs
Publication statusPublished - Apr 22 2005
Externally publishedYes

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Glycopeptides
Polymers
Water
Sugars
Amino acids
Amino Acids
Molecules

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Molecular transporter between polymer platforms : Highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports. / Fumoto, Masataka; Hinou, Hiroshi; Matsushita, Takahiko; Kurogochi, Masaki; Ohta, Takashi; Ito, Takaomi; Yamada, Kuriko; Takimoto, Akio; Kondo, Hirosato; Inazu, Toshiyuki; Nishimura, Shin Ichiro.

In: Angewandte Chemie - International Edition, Vol. 44, No. 17, 22.04.2005, p. 2534-2537.

Research output: Contribution to journalArticle

Fumoto, Masataka ; Hinou, Hiroshi ; Matsushita, Takahiko ; Kurogochi, Masaki ; Ohta, Takashi ; Ito, Takaomi ; Yamada, Kuriko ; Takimoto, Akio ; Kondo, Hirosato ; Inazu, Toshiyuki ; Nishimura, Shin Ichiro. / Molecular transporter between polymer platforms : Highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 17. pp. 2534-2537.
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