Molecular transporter between polymer platforms: Highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports

Masataka Fumoto, Hiroshi Hinou, Takahiko Matsushita, Masaki Kurogochi, Takashi Ohta, Takaomi Ito, Kuriko Yamada, Akio Takimoto, Hirosato Kondo, Toshiyuki Inazu, Shin Ichiro Nishimura

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

(Figure Presented) The molecule standing at platform one ...: Rapid glycopeptide synthesis is achieved with a heterobifunctional "molecular transporter" (see scheme), which interfaces two types of polymer platforms for combined chemical and enzymatic synthesis. This linker allows both chemoselective blotting and photoselective cleavage of the glycopeptides. Red: sugar residues; green: amino acid residues.

Original languageEnglish
Pages (from-to)2534-2537
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number17
DOIs
Publication statusPublished - Apr 22 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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