Molecular vibrational imaging of a human cell by multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum light source

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Abstract

Molecular vibrational images of human cells are obtained by multiplex coherent anti-Stokes Raman scattering (CARS) microspectroscopy. The CARS images of HeLa cells at the C-H stretching vibrational mode clearly show various organelles such as nucleolus, chromosome, cell membrane, and nuclear membrane with high vibrational contrast. Filament-like structures are also found to be observed in interphase, while it is not clearly observed in M phase. These structures most probably visualize endoplasmic reticulum (ER) network.

Original languageEnglish
Pages (from-to)1649-1652
Number of pages4
JournalJournal of Raman Spectroscopy
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Spectroscopy

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