Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy

Moyoko Tomiyasu, Takayuki Obata, Yukio Nishi, Hiromitsu Nakamoto, Hiroi Nonaka, Yukihisa Takayama, Joonas Autio, Hiroo Ikehira, Iwao Kanno

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To investigate the relationship between liver glucose, glycogen, and plasma glucose in diabetic patients, in vivo liver carbon-13 magnetic resonance spectroscopy (13C MRS) with a clinical 3.0 T MR system was performed. Subjects were healthy male volunteers (n = 5) and male type-2 diabetic patients (n = 5). Pre- and during oral glucose tolerance tests (OGTT), 13C MR spectra without proton decoupling were acquired in a monitoring period of over 6 h, and in total seven spectra were obtained from each subject. For OGTT, 75 g of glucose, including 5 g of [1-13C]glucose, was administered. The MR signals of liver [1-13C]glucose and glycogen were detected and their time-course changes were assessed in comparison with the plasma data obtained at screening. The correlations between the fasting plasma glucose level and liver glycogen/glucose rate (Spearman: ρ = -0.68, p < 0.05, n = 10) and the fasting plasma glucose level and liver glycogen peak/fasting rate (Spearman: ρ = -0.67, p < 0.05, n = 10) indicated that 13C MRS can perform noninvasive measurement of glycogen storage/degradation ability in the liver individually and can assist in tailor-made therapy for diabetes. In conclusion, 13C MRS has a potential to become a powerful tool in diagnosing diabetes multilaterally.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalEuropean Journal of Radiology
Volume73
Issue number2
DOIs
Publication statusPublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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