Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Fumiya Mito, Toshihide Yamasaki, Yuko Ito, Mayumi Yamato, Hiroyuki Mino, Hiromi Sadasue, Chisato Shirahama, Kiyoshi Sakai, Hideo Utsumi, Ken Ichi Yamada

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9 Citations (Scopus)

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer’s disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Original languageEnglish
Pages (from-to)5070-5072
Number of pages3
JournalChemical Communications
Volume47
Issue number17
DOIs
Publication statusPublished - May 7 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Mito, F., Yamasaki, T., Ito, Y., Yamato, M., Mino, H., Sadasue, H., Shirahama, C., Sakai, K., Utsumi, H., & Yamada, K. I. (2011). Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical. Chemical Communications, 47(17), 5070-5072. https://doi.org/10.1039/c0cc05764a