Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei

A. Nohtomi, M. Itoh, N. Yufu, M. Fukahori, H. Kawasaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To examine the role of monoamines in regulating β-endorphin levels in discrete brain nuclei, the levels of β-endorphin-like immunoreactivity (β-ENDi) were determined in the hypothalamic nuclei of rats 2h after they were treated with monoaminergic drugs. Sulpiride decreased the levels of β-ENDi in the nucleus paraventricularis, nucleus arcuatus and median eminence. Domperidone decreased the levels of β-ENDi in the nucleus aracuatus and median eminence. L-DOPA increased the levels of β-ENDi in the nucleus anterior hypothalami and median eminence. Phenylephrine or prazosine did not alter the levels of β-ENDi. Yohimine decreased the levels of β-ENDI in the nucleus anterior hypothalami. Isoproterenol increased the levels of β-ENDi in the nucleus arcuatus, and propranolol reversed this effect. These results suggest that dopamine and noradrenaline (via β-adrenoceptors) may regulate β-endorphinergic neurons in the rat hypothalamus.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalNeuropeptides
Volume13
Issue number4
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Endorphins
Median Eminence
Anterior Hypothalamic Nucleus
Rats
Domperidone
Sulpiride
Phenylephrine
Isoproterenol
Propranolol
Adrenergic Receptors
Neurons
Dopamine
Brain
Norepinephrine
Hypothalamus
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei. / Nohtomi, A.; Itoh, M.; Yufu, N.; Fukahori, M.; Kawasaki, H.

In: Neuropeptides, Vol. 13, No. 4, 1989, p. 285-289.

Research output: Contribution to journalArticle

Nohtomi, A. ; Itoh, M. ; Yufu, N. ; Fukahori, M. ; Kawasaki, H. / Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei. In: Neuropeptides. 1989 ; Vol. 13, No. 4. pp. 285-289.
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AU - Kawasaki, H.

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