Abstract
To examine the role of monoamines in regulating β-endorphin levels in discrete brain nuclei, the levels of β-endorphin-like immunoreactivity (β-ENDi) were determined in the hypothalamic nuclei of rats 2h after they were treated with monoaminergic drugs. Sulpiride decreased the levels of β-ENDi in the nucleus paraventricularis, nucleus arcuatus and median eminence. Domperidone decreased the levels of β-ENDi in the nucleus aracuatus and median eminence. L-DOPA increased the levels of β-ENDi in the nucleus anterior hypothalami and median eminence. Phenylephrine or prazosine did not alter the levels of β-ENDi. Yohimine decreased the levels of β-ENDI in the nucleus anterior hypothalami. Isoproterenol increased the levels of β-ENDi in the nucleus arcuatus, and propranolol reversed this effect. These results suggest that dopamine and noradrenaline (via β-adrenoceptors) may regulate β-endorphinergic neurons in the rat hypothalamus.
| Original language | English |
|---|---|
| Pages (from-to) | 285-289 |
| Number of pages | 5 |
| Journal | Neuropeptides |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Clinical Neurology
- Neuroscience(all)
- Cellular and Molecular Neuroscience
Cite this
Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei. / Nohtomi, A.; Itoh, M.; Yufu, N.; Fukahori, M.; Kawasaki, H.
In: Neuropeptides, Vol. 13, No. 4, 1989, p. 285-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei
AU - Nohtomi, A.
AU - Itoh, M.
AU - Yufu, N.
AU - Fukahori, M.
AU - Kawasaki, H.
PY - 1989
Y1 - 1989
N2 - To examine the role of monoamines in regulating β-endorphin levels in discrete brain nuclei, the levels of β-endorphin-like immunoreactivity (β-ENDi) were determined in the hypothalamic nuclei of rats 2h after they were treated with monoaminergic drugs. Sulpiride decreased the levels of β-ENDi in the nucleus paraventricularis, nucleus arcuatus and median eminence. Domperidone decreased the levels of β-ENDi in the nucleus aracuatus and median eminence. L-DOPA increased the levels of β-ENDi in the nucleus anterior hypothalami and median eminence. Phenylephrine or prazosine did not alter the levels of β-ENDi. Yohimine decreased the levels of β-ENDI in the nucleus anterior hypothalami. Isoproterenol increased the levels of β-ENDi in the nucleus arcuatus, and propranolol reversed this effect. These results suggest that dopamine and noradrenaline (via β-adrenoceptors) may regulate β-endorphinergic neurons in the rat hypothalamus.
AB - To examine the role of monoamines in regulating β-endorphin levels in discrete brain nuclei, the levels of β-endorphin-like immunoreactivity (β-ENDi) were determined in the hypothalamic nuclei of rats 2h after they were treated with monoaminergic drugs. Sulpiride decreased the levels of β-ENDi in the nucleus paraventricularis, nucleus arcuatus and median eminence. Domperidone decreased the levels of β-ENDi in the nucleus aracuatus and median eminence. L-DOPA increased the levels of β-ENDi in the nucleus anterior hypothalami and median eminence. Phenylephrine or prazosine did not alter the levels of β-ENDi. Yohimine decreased the levels of β-ENDI in the nucleus anterior hypothalami. Isoproterenol increased the levels of β-ENDi in the nucleus arcuatus, and propranolol reversed this effect. These results suggest that dopamine and noradrenaline (via β-adrenoceptors) may regulate β-endorphinergic neurons in the rat hypothalamus.
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U2 - 10.1016/0143-4179(89)90083-8
DO - 10.1016/0143-4179(89)90083-8
M3 - Article
VL - 13
SP - 285
EP - 289
JO - Neuropeptides
JF - Neuropeptides
SN - 0143-4179
IS - 4
ER -