Monoaminergic regulation of the levels of β-endorphin-like immunoreactivity (β-ENDi) in rat hypothalamic nuclei

A. Nohtomi, M. Itoh, N. Yufu, M. Fukahori, H. Kawasaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To examine the role of monoamines in regulating β-endorphin levels in discrete brain nuclei, the levels of β-endorphin-like immunoreactivity (β-ENDi) were determined in the hypothalamic nuclei of rats 2h after they were treated with monoaminergic drugs. Sulpiride decreased the levels of β-ENDi in the nucleus paraventricularis, nucleus arcuatus and median eminence. Domperidone decreased the levels of β-ENDi in the nucleus aracuatus and median eminence. L-DOPA increased the levels of β-ENDi in the nucleus anterior hypothalami and median eminence. Phenylephrine or prazosine did not alter the levels of β-ENDi. Yohimine decreased the levels of β-ENDI in the nucleus anterior hypothalami. Isoproterenol increased the levels of β-ENDi in the nucleus arcuatus, and propranolol reversed this effect. These results suggest that dopamine and noradrenaline (via β-adrenoceptors) may regulate β-endorphinergic neurons in the rat hypothalamus.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalNeuropeptides
Volume13
Issue number4
DOIs
Publication statusPublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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