Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita, Chikao Morimoto, Stuart F. Schlossman, Takehiko Sasazuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalHuman Immunology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 1988

Fingerprint

Cryptomeria
Pollen
Monoclonal Antibodies
Immunoglobulin E
Antigens
Helper-Inducer T-Lymphocytes
CD29 Antigens
CD8-Positive T-Lymphocytes
T-Lymphocytes
CD4 Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen. / Matsushita, Sho; Morimoto, Chikao; Schlossman, Stuart F.; Sasazuki, Takehiko.

In: Human Immunology, Vol. 22, No. 1, 01.01.1988, p. 1-7.

Research output: Contribution to journalArticle

Matsushita, Sho ; Morimoto, Chikao ; Schlossman, Stuart F. ; Sasazuki, Takehiko. / Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen. In: Human Immunology. 1988 ; Vol. 22, No. 1. pp. 1-7.
@article{93c7f94b23414c2f880ac9bb3c5ef01d,
title = "Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen",
abstract = "The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.",
author = "Sho Matsushita and Chikao Morimoto and Schlossman, {Stuart F.} and Takehiko Sasazuki",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0198-8859(88)90046-8",
language = "English",
volume = "22",
pages = "1--7",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

AU - Matsushita, Sho

AU - Morimoto, Chikao

AU - Schlossman, Stuart F.

AU - Sasazuki, Takehiko

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

AB - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

UR - http://www.scopus.com/inward/record.url?scp=0023948577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023948577&partnerID=8YFLogxK

U2 - 10.1016/0198-8859(88)90046-8

DO - 10.1016/0198-8859(88)90046-8

M3 - Article

C2 - 2968965

AN - SCOPUS:0023948577

VL - 22

SP - 1

EP - 7

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 1

ER -