Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita, Chikao Morimoto, Stuart F. Schlossman, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalHuman Immunology
Volume22
Issue number1
DOIs
Publication statusPublished - May 1988

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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