Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita; Chikao Morimoto; Stuart F. Schlossman; Takehiko Sasazuki

doi:10.1016/0198-8859(88)90046-8

Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita, Chikao Morimoto, Stuart F. Schlossman, Takehiko Sasazuki

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The monoclonal antibody 4B4 blocked the T8⁺ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4⁺ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Human Immunology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(88)90046-8
Publication status	Published - May 1988

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/0198-8859(88)90046-8

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@article{93c7f94b23414c2f880ac9bb3c5ef01d,

title = "Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen",

abstract = "The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.",

author = "Sho Matsushita and Chikao Morimoto and Schlossman, {Stuart F.} and Takehiko Sasazuki",

note = "Funding Information: ACKNOWLEDGMENT This work was supported in part by Grants-in-Aid 59480339(1984,1985,1986), 59870019(1984,1985,1986) and 60480177(1985,1986) from the Ministry of Education, Culture and Science, Japan, a Research Grant for Intractable Disease from the Ministry of Health and Welfare, Japan, and by N|H grants A| 12069, CA 19589 and AM 33713.",

year = "1988",

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doi = "10.1016/0198-8859(88)90046-8",

language = "English",

volume = "22",

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journal = "Human Immunology",

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T1 - Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

AU - Matsushita, Sho

AU - Morimoto, Chikao

AU - Schlossman, Stuart F.

AU - Sasazuki, Takehiko

N1 - Funding Information: ACKNOWLEDGMENT This work was supported in part by Grants-in-Aid 59480339(1984,1985,1986), 59870019(1984,1985,1986) and 60480177(1985,1986) from the Ministry of Education, Culture and Science, Japan, a Research Grant for Intractable Disease from the Ministry of Health and Welfare, Japan, and by N|H grants A| 12069, CA 19589 and AM 33713.

PY - 1988/5

Y1 - 1988/5

N2 - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

AB - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

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Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Abstract

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