Abstract
Expression of CD4 or CD8 on the cell surface is an important guide for discriminating the immunologic functions of T‐cells. However, a minor T‐cell subset lacking both CD4 and CD8 molecules but bearing the usual form of T‐cell receptor (TCR)‐αβ (CD4−CD8−TCR‐αβ+ T‐cells) has recently been found not only in mice but also in humans, and the clinical relevance of this newly defined subpopulation to human diseases is now of considerable interest. The authors present a patient in whom CD4−CD8−TCR‐αβ+ T‐cells showed monoclonal proliferation in the peripheral blood for more than 3 years, then disappeared spontaneously, followed by subsequent development of Hodgkin's disease. The pathologic roles of double‐negative T‐cell proliferation in this case are discussed from the viewpoint of premalignancy in lymphoproliferative diseases. Cancer 1994; 73:2818–23.
| Original language | English |
|---|---|
| Pages (from-to) | 2818-2823 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 73 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jun 1 1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Monoclonal proliferation of double‐negative (CD4−CD8−) T‐cells bearing T‐Cell receptor‐αβ followed by subsequent development of Hodgkin's disease. / Matsumoto, Mitsuru; Takada, Kiyonori; Hato, Takaaki; Horiuchi, Takahiko; Yasukawa, Masaki; Murao, Shinichi; Fujita, Shigeru.
In: Cancer, Vol. 73, No. 11, 01.06.1994, p. 2818-2823.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monoclonal proliferation of double‐negative (CD4−CD8−) T‐cells bearing T‐Cell receptor‐αβ followed by subsequent development of Hodgkin's disease
AU - Matsumoto, Mitsuru
AU - Takada, Kiyonori
AU - Hato, Takaaki
AU - Horiuchi, Takahiko
AU - Yasukawa, Masaki
AU - Murao, Shinichi
AU - Fujita, Shigeru
PY - 1994/6/1
Y1 - 1994/6/1
N2 - Expression of CD4 or CD8 on the cell surface is an important guide for discriminating the immunologic functions of T‐cells. However, a minor T‐cell subset lacking both CD4 and CD8 molecules but bearing the usual form of T‐cell receptor (TCR)‐αβ (CD4−CD8−TCR‐αβ+ T‐cells) has recently been found not only in mice but also in humans, and the clinical relevance of this newly defined subpopulation to human diseases is now of considerable interest. The authors present a patient in whom CD4−CD8−TCR‐αβ+ T‐cells showed monoclonal proliferation in the peripheral blood for more than 3 years, then disappeared spontaneously, followed by subsequent development of Hodgkin's disease. The pathologic roles of double‐negative T‐cell proliferation in this case are discussed from the viewpoint of premalignancy in lymphoproliferative diseases. Cancer 1994; 73:2818–23.
AB - Expression of CD4 or CD8 on the cell surface is an important guide for discriminating the immunologic functions of T‐cells. However, a minor T‐cell subset lacking both CD4 and CD8 molecules but bearing the usual form of T‐cell receptor (TCR)‐αβ (CD4−CD8−TCR‐αβ+ T‐cells) has recently been found not only in mice but also in humans, and the clinical relevance of this newly defined subpopulation to human diseases is now of considerable interest. The authors present a patient in whom CD4−CD8−TCR‐αβ+ T‐cells showed monoclonal proliferation in the peripheral blood for more than 3 years, then disappeared spontaneously, followed by subsequent development of Hodgkin's disease. The pathologic roles of double‐negative T‐cell proliferation in this case are discussed from the viewpoint of premalignancy in lymphoproliferative diseases. Cancer 1994; 73:2818–23.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028238848&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19940601)73:11<2818::AID-CNCR2820731126>3.0.CO;2-L
DO - 10.1002/1097-0142(19940601)73:11<2818::AID-CNCR2820731126>3.0.CO;2-L
M3 - Article
C2 - 8194023
AN - SCOPUS:0028238848
VL - 73
SP - 2818
EP - 2823
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 11
ER -