Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Michael Platten, Alexandra Kretz, Ulrike Naumann, Steffen Aulwurm, Kensuke Egashira, Stefan Isenmann, Michael Weller

    Research output: Contribution to journalArticlepeer-review

    150 Citations (Scopus)

    Abstract

    Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

    Original languageEnglish
    Pages (from-to)388-392
    Number of pages5
    JournalAnnals of Neurology
    Volume54
    Issue number3
    DOIs
    Publication statusPublished - Sep 1 2003

    All Science Journal Classification (ASJC) codes

    • Neurology
    • Clinical Neurology

    Fingerprint Dive into the research topics of 'Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas'. Together they form a unique fingerprint.

    Cite this