Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Michael Platten, Alexandra Kretz, Ulrike Naumann, Steffen Aulwurm, Kensuke Egashira, Stefan Isenmann, Michael Weller

Research output: Contribution to journalArticlepeer-review

158 Citations (Scopus)

Abstract

Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalAnnals of Neurology
Volume54
Issue number3
DOIs
Publication statusPublished - Sep 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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