Monodispersed polymeric nanocapsules: spontaneous evolution and morphology transition from reducible hetero-PEG PICmicelles by controlled degradation

Wen Fei Dong, Akihiro Kishimura, Yasutaka Anraku, Sayan Chuanoi, Kazunori Kataoka

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124 Citations (Scopus)

Abstract

In this communication, a novel "self-templating" strategy was used to prepare uniform and biocompatible nanocapsules by the addition of a reduction agent (i.e., DTT) into a solution of highly monodispersed PICmicelles bearing a heterodetachable PEG corona. PEG chains were released from PICmicelle shells following disulfide reduction which leads a spontaneous and drastic morphology evolution from micelles to vesicles induced by the decrease of the PEG weight fraction. Formation of uniform nanocapsules with controllable capsule size was achieved by careful control of the micelle composition and molecular weight of homo-P[Asp(DET)].

Original languageEnglish
Pages (from-to)3804-3805
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number11
DOIs
Publication statusPublished - Mar 25 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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