Monolayer Properties of Hydrophobic α-Helical Peptides Having Various End Groups at the Air/Water Interface

Katsuhiko Fujita, Shunsaku Kimura, Yukio Imanishi, Elmar Rump, Helmut Ringsdorf

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A hydrophobic peptide, Boc-(Ala-Aib)8-OMe (BA16M), and its end-modified derivatives were synthesized, and the pressure-area (π-A) isotherms of the peptides spread at the air/water interface were studied from the viewpoint of interhelix interactions. All π-A isotherms of the synthetic peptides showed an inflection and weak irregular bumping at a surface areas of about 240 and 230 Å2/molecule, respectively, indicating that the helix axis of the peptide is oriented parallel to the interface. A small mound was observed at around 300 Å2/molecule in the π-a isotherm of BA16M, which was ascribed to the phase transition from a liquid to a solid state. The monolayer of an equimolar mixture of the peptides having an opposite kind of charge in the end group underwent the phase transition in the π-A isotherm, which was not observed with one of the two peptides. The electrostatic interaction between the end groups should stabilize the molecular packing at the interface.

Original languageEnglish
Pages (from-to)2731-2735
Number of pages5
JournalLangmuir
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 1 1994

Fingerprint

Peptides
peptides
Monolayers
Isotherms
Water
air
isotherms
Air
water
Phase transitions
Molecules
Coulomb interactions
helices
molecules
interactions
electrostatics
Derivatives
solid state
Liquids
liquids

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Monolayer Properties of Hydrophobic α-Helical Peptides Having Various End Groups at the Air/Water Interface. / Fujita, Katsuhiko; Kimura, Shunsaku; Imanishi, Yukio; Rump, Elmar; Ringsdorf, Helmut.

In: Langmuir, Vol. 10, No. 8, 01.08.1994, p. 2731-2735.

Research output: Contribution to journalArticle

Fujita, Katsuhiko ; Kimura, Shunsaku ; Imanishi, Yukio ; Rump, Elmar ; Ringsdorf, Helmut. / Monolayer Properties of Hydrophobic α-Helical Peptides Having Various End Groups at the Air/Water Interface. In: Langmuir. 1994 ; Vol. 10, No. 8. pp. 2731-2735.
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