Abstract
Background: The association of morning and evening home blood pressures (HBPs) with carotid atherosclerosis has been uncertain in general populations, so we aimed to investigate it in a general Japanese population. Methods and Results: We performed a cross-sectional survey of 2,856 community-dwelling individuals aged ≥40 years to examine the association of morning and evening HBPs with carotid mean intima-media thickness (IMT). The age- and sex-adjusted geometric averages of carotid mean IMT increased significantly with increasing morning HBP (optimal: 0.67mm; normal: 0.69 mm; high normal: 0.72 mm; grade 1 hypertension: 0.74 mm; and grade 2+3 hypertension: 0.76 mm) and with increasing evening HBP (0.68 mm, 0.71mm, 0.73mm, 0.76mm, and 0.78mm, respectively) (both P for trend <0.001). These associations remained significant even after adjusting for potential confounding factors. Likewise, both isolated morning hypertension (morning HBP ≥135/85 mmHg and evening HBP <135/85 mmHg) and isolated evening hypertension (evening HBP ≥135/85 mmHg and morning HBP <135/85 mmHg) as well as sustained hypertension (both morning and evening HBP ≥135/85 mmHg) were significantly associated with thicker mean IMT. Conclusions: Our findings suggested that both morning and evening HBPs were significantly associated with carotid atherosclerosis in this general Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 1647-1653 |
| Number of pages | 7 |
| Journal | Circulation Journal |
| Volume | 81 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Morning and evening blood pressures are associated with intima-media thickness in a general population : The hisayama study. / Sakata, Satoko; Hata, Jun; Fukuhara, Masayo; Yonemoto, Koji; Mukai, Naoko; Yoshida, Daigo; Kishimoto, Hiro; Ohtsubo, Toshio; Kitazono, Takanari; Kiyohara, Yutaka; Ninomiya, Toshiharu.
In: Circulation Journal, Vol. 81, No. 11, 01.01.2017, p. 1647-1653.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morning and evening blood pressures are associated with intima-media thickness in a general population
T2 - The hisayama study
AU - Sakata, Satoko
AU - Hata, Jun
AU - Fukuhara, Masayo
AU - Yonemoto, Koji
AU - Mukai, Naoko
AU - Yoshida, Daigo
AU - Kishimoto, Hiro
AU - Ohtsubo, Toshio
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
AU - Ninomiya, Toshiharu
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: The association of morning and evening home blood pressures (HBPs) with carotid atherosclerosis has been uncertain in general populations, so we aimed to investigate it in a general Japanese population. Methods and Results: We performed a cross-sectional survey of 2,856 community-dwelling individuals aged ≥40 years to examine the association of morning and evening HBPs with carotid mean intima-media thickness (IMT). The age- and sex-adjusted geometric averages of carotid mean IMT increased significantly with increasing morning HBP (optimal: 0.67mm; normal: 0.69 mm; high normal: 0.72 mm; grade 1 hypertension: 0.74 mm; and grade 2+3 hypertension: 0.76 mm) and with increasing evening HBP (0.68 mm, 0.71mm, 0.73mm, 0.76mm, and 0.78mm, respectively) (both P for trend <0.001). These associations remained significant even after adjusting for potential confounding factors. Likewise, both isolated morning hypertension (morning HBP ≥135/85 mmHg and evening HBP <135/85 mmHg) and isolated evening hypertension (evening HBP ≥135/85 mmHg and morning HBP <135/85 mmHg) as well as sustained hypertension (both morning and evening HBP ≥135/85 mmHg) were significantly associated with thicker mean IMT. Conclusions: Our findings suggested that both morning and evening HBPs were significantly associated with carotid atherosclerosis in this general Japanese population.
AB - Background: The association of morning and evening home blood pressures (HBPs) with carotid atherosclerosis has been uncertain in general populations, so we aimed to investigate it in a general Japanese population. Methods and Results: We performed a cross-sectional survey of 2,856 community-dwelling individuals aged ≥40 years to examine the association of morning and evening HBPs with carotid mean intima-media thickness (IMT). The age- and sex-adjusted geometric averages of carotid mean IMT increased significantly with increasing morning HBP (optimal: 0.67mm; normal: 0.69 mm; high normal: 0.72 mm; grade 1 hypertension: 0.74 mm; and grade 2+3 hypertension: 0.76 mm) and with increasing evening HBP (0.68 mm, 0.71mm, 0.73mm, 0.76mm, and 0.78mm, respectively) (both P for trend <0.001). These associations remained significant even after adjusting for potential confounding factors. Likewise, both isolated morning hypertension (morning HBP ≥135/85 mmHg and evening HBP <135/85 mmHg) and isolated evening hypertension (evening HBP ≥135/85 mmHg and morning HBP <135/85 mmHg) as well as sustained hypertension (both morning and evening HBP ≥135/85 mmHg) were significantly associated with thicker mean IMT. Conclusions: Our findings suggested that both morning and evening HBPs were significantly associated with carotid atherosclerosis in this general Japanese population.
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U2 - 10.1253/circj.CJ-16-1306
DO - 10.1253/circj.CJ-16-1306
M3 - Article
VL - 81
SP - 1647
EP - 1653
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 11
ER -