Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum

Shiro Egawa, Daisuke Saito, Gembu Abe, Koji Tamura

Research output: Contribution to journalArticle

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Abstract

Understanding morphological evolution in dinosaurs from a mechanistic viewpoint requires the elucidation of the morphogenesis that gave rise to derived dinosaurian traits, such as the perforated acetabulum. In the current study, we used embryos of extant animals with ancestral- and dinosaur-type acetabula, namely, geckos and turtles (with unperforated acetabulum), and birds (with perforated acetabulum). We performed comparative and experimental analyses, focusing on inter-tissue interaction during embryogenesis, and found that the avian perforated acetabulum develops via a secondary loss of cartilaginous tissue in the acetabular region. This cartilage loss might be mediated by inter-tissue interaction with the hip interzone, a mesenchymal tissue that exists in the embryonic joint structure. Furthermore, the data indicate that avian pelvic anlagen is more susceptible to paracrine molecules, e.g. Wnt ligand, secreted by the hip interzone than 'reptilian' anlagen. We hypothesize that during the emergence of dinosaurs, the pelvic anlagen became susceptible to the Wnt ligand, which led to the loss of the cartilaginous tissue and to the perforation in the acetabular region. Thus, the current evolutionary-developmental biology study deepens our understanding of morphological evolution in dinosaurs and provides it with a novel perspective.

Original languageEnglish
Article number180604
JournalRoyal Society Open Science
Volume5
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Dinosaurs
Acetabulum
Hip
Embryonic Structures
Ligands
Developmental Biology
Turtles
Lizards
Morphogenesis
Cartilage
Birds
Embryonic Development
Joints

All Science Journal Classification (ASJC) codes

  • General

Cite this

Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum. / Egawa, Shiro; Saito, Daisuke; Abe, Gembu; Tamura, Koji.

In: Royal Society Open Science, Vol. 5, No. 10, 180604, 01.10.2018.

Research output: Contribution to journalArticle

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