Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called 'dysplastic nodule-carcinoma' sequence?

Ken Ichi Taguchi, Yoshiki Asayama, Shin Ichi Aishima, Hidehiro Nishi, Keishi Sugimachi, Shuji Matsuura, Takahiro Terashi, Takeharu Yamanaka, Mitsuo Shimada, Keizo Sugimachi, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8%) and 35 of type B (31.2%). The frequency of type A in cirrhotic group (74.7%) is statistically higher than that of non-cirrhotic group (54.5%) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalOncology reports
Volume9
Issue number4
Publication statusPublished - Jul 1 2002

Fingerprint

Hepatocellular Carcinoma
Carcinoma
Fibrosis
Hepatitis B Surface Antigens
Hepatitis B virus
Neoplasms
Multivariate Analysis
Liver
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Taguchi, K. I., Asayama, Y., Aishima, S. I., Nishi, H., Sugimachi, K., Matsuura, S., ... Tsuneyoshi, M. (2002). Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called 'dysplastic nodule-carcinoma' sequence? Oncology reports, 9(4), 737-743.

Morphologic approach to hepatocellular carcinoma development in man : De novo or the so-called 'dysplastic nodule-carcinoma' sequence? / Taguchi, Ken Ichi; Asayama, Yoshiki; Aishima, Shin Ichi; Nishi, Hidehiro; Sugimachi, Keishi; Matsuura, Shuji; Terashi, Takahiro; Yamanaka, Takeharu; Shimada, Mitsuo; Sugimachi, Keizo; Tsuneyoshi, Masazumi.

In: Oncology reports, Vol. 9, No. 4, 01.07.2002, p. 737-743.

Research output: Contribution to journalArticle

Taguchi, KI, Asayama, Y, Aishima, SI, Nishi, H, Sugimachi, K, Matsuura, S, Terashi, T, Yamanaka, T, Shimada, M, Sugimachi, K & Tsuneyoshi, M 2002, 'Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called 'dysplastic nodule-carcinoma' sequence?', Oncology reports, vol. 9, no. 4, pp. 737-743.
Taguchi, Ken Ichi ; Asayama, Yoshiki ; Aishima, Shin Ichi ; Nishi, Hidehiro ; Sugimachi, Keishi ; Matsuura, Shuji ; Terashi, Takahiro ; Yamanaka, Takeharu ; Shimada, Mitsuo ; Sugimachi, Keizo ; Tsuneyoshi, Masazumi. / Morphologic approach to hepatocellular carcinoma development in man : De novo or the so-called 'dysplastic nodule-carcinoma' sequence?. In: Oncology reports. 2002 ; Vol. 9, No. 4. pp. 737-743.
@article{84ec6ef7879746e29980b3237ac3f2a4,
title = "Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called 'dysplastic nodule-carcinoma' sequence?",
abstract = "The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8{\%}) and 35 of type B (31.2{\%}). The frequency of type A in cirrhotic group (74.7{\%}) is statistically higher than that of non-cirrhotic group (54.5{\%}) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.",
author = "Taguchi, {Ken Ichi} and Yoshiki Asayama and Aishima, {Shin Ichi} and Hidehiro Nishi and Keishi Sugimachi and Shuji Matsuura and Takahiro Terashi and Takeharu Yamanaka and Mitsuo Shimada and Keizo Sugimachi and Masazumi Tsuneyoshi",
year = "2002",
month = "7",
day = "1",
language = "English",
volume = "9",
pages = "737--743",
journal = "Oncology Reports",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "4",

}

TY - JOUR

T1 - Morphologic approach to hepatocellular carcinoma development in man

T2 - De novo or the so-called 'dysplastic nodule-carcinoma' sequence?

AU - Taguchi, Ken Ichi

AU - Asayama, Yoshiki

AU - Aishima, Shin Ichi

AU - Nishi, Hidehiro

AU - Sugimachi, Keishi

AU - Matsuura, Shuji

AU - Terashi, Takahiro

AU - Yamanaka, Takeharu

AU - Shimada, Mitsuo

AU - Sugimachi, Keizo

AU - Tsuneyoshi, Masazumi

PY - 2002/7/1

Y1 - 2002/7/1

N2 - The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8%) and 35 of type B (31.2%). The frequency of type A in cirrhotic group (74.7%) is statistically higher than that of non-cirrhotic group (54.5%) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.

AB - The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8%) and 35 of type B (31.2%). The frequency of type A in cirrhotic group (74.7%) is statistically higher than that of non-cirrhotic group (54.5%) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.

UR - http://www.scopus.com/inward/record.url?scp=18744437398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744437398&partnerID=8YFLogxK

M3 - Article

C2 - 12066201

AN - SCOPUS:18744437398

VL - 9

SP - 737

EP - 743

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

IS - 4

ER -