Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans

Makoto Koga, Yasumi Ohshima

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The let-23 receptor tyrosine kinase gene is required for vulval induction and larval survival in the nematode Caenorhabditis elegans. We carried out genetic mosaic analyses of the let-23 gene function by using the cloned let-23 and ncl-1 genes. The wild-type let-23 gene was required in a vulval precursor cell to adopt the 1° vulval fate in animals carrying a let-23 vulvaless or lethal chromosomal mutation. In almost all the animals, vulval precursor cells adjacent to a 1° fate cell were induced to the 2° vulval fate regardless of the let-23 genotypes. These findings indicate that the vulval induction signal from an anchor cell induces a vulval precursor cell to adopt the 1° fate through LET-23, and then a 1° fate cell induces adjacent cells to adopt the 2° fate, for which LET-23 is not required. Foci of lethality of the let-23 (mn23) mutation were found in ABal and ABplp lineages.

Original languageEnglish
Pages (from-to)2655-2666
Number of pages12
JournalDevelopment
Volume121
Issue number8
Publication statusPublished - Aug 1 1995

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

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