Mouse models of plaque rupture

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Atherosclerotic plaque destabilization and rupture is an important pathological condition that may account for approximately 70% of acute myocardial infarction cases. To analyse the mechanisms by which an atherosclerotic plaque destabilizes and ruptures and examine the effects of novel therapeutic approaches, several groups have developed mouse models of plaque rupture. RECENT FINDINGS: Findings from intracoronary imaging modalities support the role of rupture-prone 'vulnerable plaques' characterized by pathological studies as precursors of plaque rupture and acute myocardial infarction. Atherosclerotic plaques in the brachiocephalic arteries of apolipoprotein E (ApoE)-deficient mice fed a high-fat diet demonstrate several key histological features of ruptured human plaques. Angiotensin II infusion accelerates plaque destabilization and rupture, which has enabled researchers to analyse the role of pathophysiological and genetic factors that accelerate plaque destabilization and rupture and qualitatively examine the effects of experimental therapies. The plaque rupture model in the brachiocephalic arteries of ApoE-deficient mice is disputed due to dissimilarities from human plaques regarding the incidence of thrombotic occlusion and computer-simulated mechanical stress in the plaque. SUMMARY: Although no mouse model examined completely simulates the entire process of plaque rupture, the brachiocephalic artery in ApoE-deficient mice fed a high-fat diet, with or without angiotensin II infusion, is a practically feasible model for plaque rupture.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalCurrent Opinion in Lipidology
Volume24
Issue number5
DOIs
Publication statusPublished - Oct 1 2013

Fingerprint

Rupture
Apolipoproteins E
Atherosclerotic Plaques
Arteries
High Fat Diet
Angiotensin II
Myocardial Infarction
Investigational Therapies
Mechanical Stress
Therapeutic Uses
Research Personnel
Incidence

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Genetics
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Mouse models of plaque rupture. / Matoba, Tetsuya; Sato, Kei; Egashira, Kensuke.

In: Current Opinion in Lipidology, Vol. 24, No. 5, 01.10.2013, p. 419-425.

Research output: Contribution to journalReview article

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