MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas

Hiroyuki Irie, Hiroshi Honda, Hitoshi Aibe, Toshiro Kuroiwa, Kengo Yoshimitsu, Kenji Shinozaki, Koji Yamaguchi, Mitsuo Shimada, Kouji Masuda

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154 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to establish MR cholangiopancreatographic criteria for discriminating benign from malignant intraductal mucin-producing tumors of the pancreas. MATERIALS AND METHODS. Thirty-one patients with 34 intraductal mucin-producing tumors underwent MR cholangiopancreatography. Tumors were classified as either main duct type (n = 10) or branch duct type (n = 24). In patients with the main duct type, the maximum diameter and the location of the main pancreatic duct, the extent of main pancreatic duct dilatation, and the presence of a filling defect were evaluated. For branch duct type, the location and maximum diameter of the cystic lesion, the presence of a filling defect, and the presence of associated main pancreatic duct dilatation were evaluated. RESULTS. In patients with the main duct type, the main pancreatic duct was significantly narrower when associated with benign rather than malignant tumors. All malignant tumors showed diffuse main pancreatic duct dilatation, whereas all benign tumors showed segmental dilatation. Among patients with branch duct type, the cyst was smaller when it was a benign rather than malignant tumor. All but one malignant tumor showed mild associated main pancreatic duct dilatation, whereas benign tumors were not associated with main pancreatic duct dilatation. Filling defects suggested malignancy, although half of the malignant tumors had no filling defects. CONCLUSION. In patients with intraductal mucin-producing tumors of the pancreas, filling defects are indicative of malignancy. Diffuse main pancreatic duct dilatation greater than 15 mm (main duct type), or any main pancreatic duct dilatation (branch duct type), is strongly associated with malignancy.

Original languageEnglish
Pages (from-to)1403-1408
Number of pages6
JournalAmerican Journal of Roentgenology
Volume174
Issue number5
DOIs
Publication statusPublished - Jan 1 2000

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Mucins
Pancreas
Pancreatic Ducts
Dilatation
Neoplasms
Cysts

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas. / Irie, Hiroyuki; Honda, Hiroshi; Aibe, Hitoshi; Kuroiwa, Toshiro; Yoshimitsu, Kengo; Shinozaki, Kenji; Yamaguchi, Koji; Shimada, Mitsuo; Masuda, Kouji.

In: American Journal of Roentgenology, Vol. 174, No. 5, 01.01.2000, p. 1403-1408.

Research output: Contribution to journalArticle

Irie, H, Honda, H, Aibe, H, Kuroiwa, T, Yoshimitsu, K, Shinozaki, K, Yamaguchi, K, Shimada, M & Masuda, K 2000, 'MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas', American Journal of Roentgenology, vol. 174, no. 5, pp. 1403-1408. https://doi.org/10.2214/ajr.174.5.1741403
Irie, Hiroyuki ; Honda, Hiroshi ; Aibe, Hitoshi ; Kuroiwa, Toshiro ; Yoshimitsu, Kengo ; Shinozaki, Kenji ; Yamaguchi, Koji ; Shimada, Mitsuo ; Masuda, Kouji. / MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas. In: American Journal of Roentgenology. 2000 ; Vol. 174, No. 5. pp. 1403-1408.
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AU - Irie, Hiroyuki

AU - Honda, Hiroshi

AU - Aibe, Hitoshi

AU - Kuroiwa, Toshiro

AU - Yoshimitsu, Kengo

AU - Shinozaki, Kenji

AU - Yamaguchi, Koji

AU - Shimada, Mitsuo

AU - Masuda, Kouji

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N2 - OBJECTIVE. The purpose of this study was to establish MR cholangiopancreatographic criteria for discriminating benign from malignant intraductal mucin-producing tumors of the pancreas. MATERIALS AND METHODS. Thirty-one patients with 34 intraductal mucin-producing tumors underwent MR cholangiopancreatography. Tumors were classified as either main duct type (n = 10) or branch duct type (n = 24). In patients with the main duct type, the maximum diameter and the location of the main pancreatic duct, the extent of main pancreatic duct dilatation, and the presence of a filling defect were evaluated. For branch duct type, the location and maximum diameter of the cystic lesion, the presence of a filling defect, and the presence of associated main pancreatic duct dilatation were evaluated. RESULTS. In patients with the main duct type, the main pancreatic duct was significantly narrower when associated with benign rather than malignant tumors. All malignant tumors showed diffuse main pancreatic duct dilatation, whereas all benign tumors showed segmental dilatation. Among patients with branch duct type, the cyst was smaller when it was a benign rather than malignant tumor. All but one malignant tumor showed mild associated main pancreatic duct dilatation, whereas benign tumors were not associated with main pancreatic duct dilatation. Filling defects suggested malignancy, although half of the malignant tumors had no filling defects. CONCLUSION. In patients with intraductal mucin-producing tumors of the pancreas, filling defects are indicative of malignancy. Diffuse main pancreatic duct dilatation greater than 15 mm (main duct type), or any main pancreatic duct dilatation (branch duct type), is strongly associated with malignancy.

AB - OBJECTIVE. The purpose of this study was to establish MR cholangiopancreatographic criteria for discriminating benign from malignant intraductal mucin-producing tumors of the pancreas. MATERIALS AND METHODS. Thirty-one patients with 34 intraductal mucin-producing tumors underwent MR cholangiopancreatography. Tumors were classified as either main duct type (n = 10) or branch duct type (n = 24). In patients with the main duct type, the maximum diameter and the location of the main pancreatic duct, the extent of main pancreatic duct dilatation, and the presence of a filling defect were evaluated. For branch duct type, the location and maximum diameter of the cystic lesion, the presence of a filling defect, and the presence of associated main pancreatic duct dilatation were evaluated. RESULTS. In patients with the main duct type, the main pancreatic duct was significantly narrower when associated with benign rather than malignant tumors. All malignant tumors showed diffuse main pancreatic duct dilatation, whereas all benign tumors showed segmental dilatation. Among patients with branch duct type, the cyst was smaller when it was a benign rather than malignant tumor. All but one malignant tumor showed mild associated main pancreatic duct dilatation, whereas benign tumors were not associated with main pancreatic duct dilatation. Filling defects suggested malignancy, although half of the malignant tumors had no filling defects. CONCLUSION. In patients with intraductal mucin-producing tumors of the pancreas, filling defects are indicative of malignancy. Diffuse main pancreatic duct dilatation greater than 15 mm (main duct type), or any main pancreatic duct dilatation (branch duct type), is strongly associated with malignancy.

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