MR detection of cytoplasmic fat in clear cell renal cell carcinoma utilizing chemical shift gradient-echo imaging

Kengo Yoshimitsu, Hiroshi Honda, Toshiro Kuroiwa, Hiroyuki Irie, Tsuyoshi Tajima, Makiko Jimi, Kentaro Kuroiwa, Seiji Naito, Kouji Masuda

Research output: Contribution to journalArticle

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Abstract

We attempted to determine whether cytoplasmic fat in clear cell renal cell carcinoma (RCC) can be identified by chemical shift gradient-echo magnetic resonance imaging (CSI). CSI was performed for 22 clear cell RCCs and 30 other renal tumors (including 16 non-clear cell RCCs), all of which were surgically proven. Signal reduction in out-of-phase images of these tumors was retrospectively evaluated and compared. The signal loss ratio (SLR) was defined and calculated. Fat staining of specimens from 16 tumors was performed and correlated with SLR. SLR was significantly higher in clear cell RCCs than in non-clear cell RCCs (P < 0.001). There was a significant correlation between degree of fat staining positivity of the specimens and SLR (P < 0.01). When signal reduction in out-of-phase images suggested the diagnosis of clear cell RCC, correct diagnosis of this entity was made in resected renal tumors with sensitivity, specificity, and accuracy of 82%, 90%, and 87%, respectively. CSI can demonstrate cytoplasmic fat in clear cell RCCs, which helps to differentiate this entity from other RCCs.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 1 1999

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Renal Cell Carcinoma
Fats
Neoplasms
Staining and Labeling
Kidney
Magnetic Resonance Imaging
Sensitivity and Specificity
Clear-cell metastatic renal cell carcinoma

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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MR detection of cytoplasmic fat in clear cell renal cell carcinoma utilizing chemical shift gradient-echo imaging. / Yoshimitsu, Kengo; Honda, Hiroshi; Kuroiwa, Toshiro; Irie, Hiroyuki; Tajima, Tsuyoshi; Jimi, Makiko; Kuroiwa, Kentaro; Naito, Seiji; Masuda, Kouji.

In: Journal of Magnetic Resonance Imaging, Vol. 9, No. 4, 01.04.1999, p. 579-585.

Research output: Contribution to journalArticle

Yoshimitsu, Kengo ; Honda, Hiroshi ; Kuroiwa, Toshiro ; Irie, Hiroyuki ; Tajima, Tsuyoshi ; Jimi, Makiko ; Kuroiwa, Kentaro ; Naito, Seiji ; Masuda, Kouji. / MR detection of cytoplasmic fat in clear cell renal cell carcinoma utilizing chemical shift gradient-echo imaging. In: Journal of Magnetic Resonance Imaging. 1999 ; Vol. 9, No. 4. pp. 579-585.
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