MR imaging of hepatocellular carcinoma: Correlation of metal content and signal intensity

H. Honda, H. Onitsuka, Y. Kanazawa, T. Matsumata, T. Hayashi, K. Kaneko, T. Fukuya, Y. Tateshi, E. Adachi, K. Masuda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalActa Radiologica
Volume36
Issue number2
DOIs
Publication statusPublished - Mar 1995

Fingerprint

Hepatocellular Carcinoma
Metals
Liver
Manganese
Copper
Iron
Ions
Lipids
Water
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Honda, H., Onitsuka, H., Kanazawa, Y., Matsumata, T., Hayashi, T., Kaneko, K., ... Masuda, K. (1995). MR imaging of hepatocellular carcinoma: Correlation of metal content and signal intensity. Acta Radiologica, 36(2), 163-167. https://doi.org/10.1177/028418519503600211

MR imaging of hepatocellular carcinoma : Correlation of metal content and signal intensity. / Honda, H.; Onitsuka, H.; Kanazawa, Y.; Matsumata, T.; Hayashi, T.; Kaneko, K.; Fukuya, T.; Tateshi, Y.; Adachi, E.; Masuda, K.

In: Acta Radiologica, Vol. 36, No. 2, 03.1995, p. 163-167.

Research output: Contribution to journalArticle

Honda, H, Onitsuka, H, Kanazawa, Y, Matsumata, T, Hayashi, T, Kaneko, K, Fukuya, T, Tateshi, Y, Adachi, E & Masuda, K 1995, 'MR imaging of hepatocellular carcinoma: Correlation of metal content and signal intensity', Acta Radiologica, vol. 36, no. 2, pp. 163-167. https://doi.org/10.1177/028418519503600211
Honda H, Onitsuka H, Kanazawa Y, Matsumata T, Hayashi T, Kaneko K et al. MR imaging of hepatocellular carcinoma: Correlation of metal content and signal intensity. Acta Radiologica. 1995 Mar;36(2):163-167. https://doi.org/10.1177/028418519503600211
Honda, H. ; Onitsuka, H. ; Kanazawa, Y. ; Matsumata, T. ; Hayashi, T. ; Kaneko, K. ; Fukuya, T. ; Tateshi, Y. ; Adachi, E. ; Masuda, K. / MR imaging of hepatocellular carcinoma : Correlation of metal content and signal intensity. In: Acta Radiologica. 1995 ; Vol. 36, No. 2. pp. 163-167.
@article{2f12557b72c047f39e68e0f21f181140,
title = "MR imaging of hepatocellular carcinoma: Correlation of metal content and signal intensity",
abstract = "In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.",
author = "H. Honda and H. Onitsuka and Y. Kanazawa and T. Matsumata and T. Hayashi and K. Kaneko and T. Fukuya and Y. Tateshi and E. Adachi and K. Masuda",
year = "1995",
month = "3",
doi = "10.1177/028418519503600211",
language = "English",
volume = "36",
pages = "163--167",
journal = "Acta Radiologica",
issn = "0284-1851",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - MR imaging of hepatocellular carcinoma

T2 - Correlation of metal content and signal intensity

AU - Honda, H.

AU - Onitsuka, H.

AU - Kanazawa, Y.

AU - Matsumata, T.

AU - Hayashi, T.

AU - Kaneko, K.

AU - Fukuya, T.

AU - Tateshi, Y.

AU - Adachi, E.

AU - Masuda, K.

PY - 1995/3

Y1 - 1995/3

N2 - In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.

AB - In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.

UR - http://www.scopus.com/inward/record.url?scp=0029257122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029257122&partnerID=8YFLogxK

U2 - 10.1177/028418519503600211

DO - 10.1177/028418519503600211

M3 - Article

C2 - 7710797

AN - SCOPUS:0029257122

VL - 36

SP - 163

EP - 167

JO - Acta Radiologica

JF - Acta Radiologica

SN - 0284-1851

IS - 2

ER -