MR imaging of hepatocellular carcinomas

Effect of Cu and Fe contents on signal intensity

Hiroshi Honda, K. Kaneko, Y. Kanazawa, T. Hayashi, T. Fukuya, T. Matsumata, T. Maeda, K. Masuda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: To elucidate the metallic factors contributing to the signal intensities of hepatocellular carcinoma (HCC) on T1-weighted magnetic resonance (MR) images and to determine whether or not changes in signal intensity contribute to the diagnosis of histological grading of HCC. Methods: In 35 patients immediately after surgery, the quantities of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) were determined in HCCs and the surrounding hepatic parenchyma. The correlations among these findings, the histopathological findings, and the signal intensities of T1-weighted MR images were evaluated. Results: Among the 35 HCCs, 12 (34%) were of high intensity, 14 (40%) were isointense, and 9 (26%) were of low intensity on T1- weighted images versus the surrounding hepatic parenchyma. The paramagnetic ions, which contributed to the signal intensity patterns, were assumed to be Cu in HCCs (30.5 ± 52.9 μg/g ww), and Fe in the livers (106.2 ± 86.8 μg/g ww) and HCCs (87.7 ± 49.1 μg/g ww). In 12 HCCs with high intensity, one was grade I, eight were grade II, and three were grade III according to Edmondson-Steiner's histopathological classification. Conclusions: Signal intensity and signal intensity patterns alone cannot be signs of low-grade malignancy because of the Fe in livers and in HCCs.

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalAbdominal Imaging
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 22 1997

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Hepatocellular Carcinoma
Magnetic Resonance Imaging
Liver
Magnetic Resonance Spectroscopy
Manganese
Copper
Iron
Ions
Lipids
Water
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

Honda, H., Kaneko, K., Kanazawa, Y., Hayashi, T., Fukuya, T., Matsumata, T., ... Masuda, K. (1997). MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity. Abdominal Imaging, 22(1), 60-66. https://doi.org/10.1007/s002619900141

MR imaging of hepatocellular carcinomas : Effect of Cu and Fe contents on signal intensity. / Honda, Hiroshi; Kaneko, K.; Kanazawa, Y.; Hayashi, T.; Fukuya, T.; Matsumata, T.; Maeda, T.; Masuda, K.

In: Abdominal Imaging, Vol. 22, No. 1, 22.01.1997, p. 60-66.

Research output: Contribution to journalArticle

Honda, H, Kaneko, K, Kanazawa, Y, Hayashi, T, Fukuya, T, Matsumata, T, Maeda, T & Masuda, K 1997, 'MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity', Abdominal Imaging, vol. 22, no. 1, pp. 60-66. https://doi.org/10.1007/s002619900141
Honda H, Kaneko K, Kanazawa Y, Hayashi T, Fukuya T, Matsumata T et al. MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity. Abdominal Imaging. 1997 Jan 22;22(1):60-66. https://doi.org/10.1007/s002619900141
Honda, Hiroshi ; Kaneko, K. ; Kanazawa, Y. ; Hayashi, T. ; Fukuya, T. ; Matsumata, T. ; Maeda, T. ; Masuda, K. / MR imaging of hepatocellular carcinomas : Effect of Cu and Fe contents on signal intensity. In: Abdominal Imaging. 1997 ; Vol. 22, No. 1. pp. 60-66.
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