MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA

Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Tsuyoshi Tajima, Daisuke Kakihara, Tomohiro Nakayama, Yukihisa Takayama, Daisuke Okamoto, Akinobu Taketomi, Ken Shirabe, Nobuhiro Fujita, Makoto Obara, Kengo Yoshimitsu, Hiroshi Honda

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Purpose: To examine whether the uptake of a liver-specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis. Materials and Methods: This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)- and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI before liver surgery, respectively. For each patient, we calculated δR2* and δR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver-to-spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman's rank correlation test. Results: The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = -0.641; P < 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut-off value. No significant correlation was obtained between δR2* or δR2 and the degree of liver fibrosis. Conclusion: The uptake of Gd-EOB-DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664-671.

Original languageEnglish
Pages (from-to)664-671
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume36
Issue number3
DOIs
Publication statusPublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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