MR Prediction of Malignant Switch With the Cyst Fluid's T2 Value in Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Preliminary Study

Seiichiro Takao, Akihiro Nishie, Yasuhiro Ushijima, Yukihisa Takayama, Koichiro Morita, Keisuke Ishimatsu, Yutaka Koga, Yasuhisa Mori, Yuta Akamine, Kousei Ishigami

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: We investigated whether the malignant switch of intraductal papillary mucinous neoplasm (IPMN) of the pancreas can be predicted by using the T1ρ, T2, and apparent diffusion coefficient (ADC) values of cyst fluid. Patients and Methods: We retrospectively analyzed the magnetic resonance (MR) images of 60 patients (26 males, 34 females, mean age 61 years) with branch-duct type and mixed-type IPMNs. The IPMNs were diagnosed clinically in 39 patients and histologically in 21 patients. The malignant potential was classified by MR imaging based on the international consensus guidelines for the management of IPMN established in 2017. Morphologically, 42 patients had "worrisome features" and three had "high-risk stigmata." Histologically, 14 lesions were diagnosed as low-grade dysplasia and seven as intermediate-grade dysplasia. The T1ρ, T2, and ADC values of cyst fluid in each patient's largest cyst were measured on the same slice, avoiding solid components. Spearman's rank correlation test was used to determine the correlation between the morphological malignancy and the T1ρ, T2, and ADC values. These values were also compared between the low-grade and intermediate-grade groups by Mann-Whitney U-test. Results: There was a significant rank-correlation between the morphological classification and T2 value (p=0.04). The T2 value of the intermediate-grade group was significantly higher than that of the low-grade group (p=0.03). No significant correlations were morphologically or histologically obtained regarding T1ρ and ADC. Conclusion: The T2 value of cyst fluid together with other MR-signs may be useful for predicting the malignant switch in IPMN of the pancreas.

Original languageEnglish
Pages (from-to)3895-3903
Number of pages9
JournalAnticancer research
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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