TY - JOUR
T1 - MR relative cerebral blood flow mapping of Alzheimer disease
T2 - Correlation with Tc-99m HMPAO SPECT
AU - Yoshiura, Takashi
AU - Mihara, Futoshi
AU - Kuwabara, Yasuhiro
AU - Ogomori, Koji
AU - Kaneko, Koichiro
AU - Tanaka, Atsuo
AU - Sasaki, Masayuki
AU - Nakagawa, Makoto
AU - Koga, Hirofumi
AU - Yamanaka, Takeharu
AU - Masuda, Kouji
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Rationale and Objectives. To evaluate the value of magnetic resonance (MR) perfusion imaging for diagnosis of Alzheimer disease (AD), the authors compared relative cerebral blood flow (CBF) maps obtained with MR perfusion imaging and technetium-99m hexamethyl-propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) in patients with AD. Materials and Methods. Eight patients with AD were studied with MR perfusion imaging and HMPAO SPECT. The relative CBF maps from the two techniques were spatially coregistered, and relative CBF values in 13 cerebral gray matter regions (total, 26 regions of interest) were compared with regression analysis. To evaluate the degree of deviation of each brain region from the regression line, a P value for the residual was calculated for each region. Results. A significant overall correlation was seen between the relative CBF values produced by the two techniques (r = .68, P < .0001). Smaller P values for the residuals were obtained in the anterior cingulate cortex (P = .05) and posterior cingulate cortex (P < .001), indicating larger deviations in these regions. When data from these two regions were eliminated, the correlation coefficient rose to 0.80 (P < .0001). Conclusion. Despite fairly large discrepancies in the anterior and posterior cingulate cortices, the relative CBF map obtained with MR imaging is generally in close agreement with the HMPAO SPECT map, suggesting that MR perfusion imaging can provide clinically useful information regarding CBF abnormalities in patients with AD.
AB - Rationale and Objectives. To evaluate the value of magnetic resonance (MR) perfusion imaging for diagnosis of Alzheimer disease (AD), the authors compared relative cerebral blood flow (CBF) maps obtained with MR perfusion imaging and technetium-99m hexamethyl-propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) in patients with AD. Materials and Methods. Eight patients with AD were studied with MR perfusion imaging and HMPAO SPECT. The relative CBF maps from the two techniques were spatially coregistered, and relative CBF values in 13 cerebral gray matter regions (total, 26 regions of interest) were compared with regression analysis. To evaluate the degree of deviation of each brain region from the regression line, a P value for the residual was calculated for each region. Results. A significant overall correlation was seen between the relative CBF values produced by the two techniques (r = .68, P < .0001). Smaller P values for the residuals were obtained in the anterior cingulate cortex (P = .05) and posterior cingulate cortex (P < .001), indicating larger deviations in these regions. When data from these two regions were eliminated, the correlation coefficient rose to 0.80 (P < .0001). Conclusion. Despite fairly large discrepancies in the anterior and posterior cingulate cortices, the relative CBF map obtained with MR imaging is generally in close agreement with the HMPAO SPECT map, suggesting that MR perfusion imaging can provide clinically useful information regarding CBF abnormalities in patients with AD.
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U2 - 10.1016/S1076-6332(03)80665-7
DO - 10.1016/S1076-6332(03)80665-7
M3 - Article
C2 - 12553349
AN - SCOPUS:0036936693
SN - 1076-6332
VL - 9
SP - 1383
EP - 1387
JO - Academic Radiology
JF - Academic Radiology
IS - 12
ER -