MRI predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty

Danyal H. Nawabi, Stephanie Gold, Steven Lyman, Kara Fields, Douglas E. Padgett, Hollis G. Potter

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Background: Adverse local tissue reactions (ALTR) around metal-on-metal (MOM) hip arthroplasties are increasingly being recognized as a cause of failure. These reactions may be associated with intraoperative tissue damage and complication rates as high as 50% after revision. Although MRI can identify ALTR in MOM hips, it is unclear whether the MRI findings predict those at revision surgery. Questions/purposes: We therefore (1) identified which MRI characteristics correlated with histologically confirmed ALTR (using the aseptic lymphocytic vasculitis-associated lesions [ALVAL] score) and intraoperative tissue damage and (2) developed a predictive model using modified MRI to detect ALVAL and quantify intraoperative tissue damage. Methods: We retrospectively reviewed 68 patients with failed MOM hip arthroplasties who underwent preoperative MRI and subsequent revision surgery. Images were analyzed to determine synovial volume, osteolysis, and synovial thickness. The ALVAL score was used to grade tissue samples, thus identifying a subset of patients with ALTR. Intraoperative tissue damage was graded using a four-point scale. Random forest analysis determined the sensitivity and specificity of MRI characteristics in detecting ALVAL (score ≥ 5) and intraoperative tissue damage. Results: Maximal synovial thicknesses and synovial volumes as determined on MRI correlated with the ALVAL score and were higher in cases of severe intraoperative tissue damage. Our MRI predictive model showed sensitivity and specificity of 94% and 87%, respectively, for detecting ALVAL and 90% and 86%, respectively, for quantifying intraoperative tissue damage. Conclusions: MRI is sensitive and specific in detecting ALVAL and tissue damage in patients with MOM hip implants. MRI can be used as a screening tool to guide surgeons toward timely revision surgery. Level of Evidence: Level III, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.

Original languageEnglish
Pages (from-to)471-481
Number of pages11
JournalClinical orthopaedics and related research
Volume472
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Vasculitis
Arthroplasty
Hip
Metals
Reoperation
Sensitivity and Specificity
Osteolysis
Guidelines

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

MRI predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty. / Nawabi, Danyal H.; Gold, Stephanie; Lyman, Steven; Fields, Kara; Padgett, Douglas E.; Potter, Hollis G.

In: Clinical orthopaedics and related research, Vol. 472, No. 2, 02.2014, p. 471-481.

Research output: Contribution to journalArticle

Nawabi, Danyal H. ; Gold, Stephanie ; Lyman, Steven ; Fields, Kara ; Padgett, Douglas E. ; Potter, Hollis G. / MRI predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty. In: Clinical orthopaedics and related research. 2014 ; Vol. 472, No. 2. pp. 471-481.
@article{94289bdd2aff4dd5aba86db875030896,
title = "MRI predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty",
abstract = "Background: Adverse local tissue reactions (ALTR) around metal-on-metal (MOM) hip arthroplasties are increasingly being recognized as a cause of failure. These reactions may be associated with intraoperative tissue damage and complication rates as high as 50{\%} after revision. Although MRI can identify ALTR in MOM hips, it is unclear whether the MRI findings predict those at revision surgery. Questions/purposes: We therefore (1) identified which MRI characteristics correlated with histologically confirmed ALTR (using the aseptic lymphocytic vasculitis-associated lesions [ALVAL] score) and intraoperative tissue damage and (2) developed a predictive model using modified MRI to detect ALVAL and quantify intraoperative tissue damage. Methods: We retrospectively reviewed 68 patients with failed MOM hip arthroplasties who underwent preoperative MRI and subsequent revision surgery. Images were analyzed to determine synovial volume, osteolysis, and synovial thickness. The ALVAL score was used to grade tissue samples, thus identifying a subset of patients with ALTR. Intraoperative tissue damage was graded using a four-point scale. Random forest analysis determined the sensitivity and specificity of MRI characteristics in detecting ALVAL (score ≥ 5) and intraoperative tissue damage. Results: Maximal synovial thicknesses and synovial volumes as determined on MRI correlated with the ALVAL score and were higher in cases of severe intraoperative tissue damage. Our MRI predictive model showed sensitivity and specificity of 94{\%} and 87{\%}, respectively, for detecting ALVAL and 90{\%} and 86{\%}, respectively, for quantifying intraoperative tissue damage. Conclusions: MRI is sensitive and specific in detecting ALVAL and tissue damage in patients with MOM hip implants. MRI can be used as a screening tool to guide surgeons toward timely revision surgery. Level of Evidence: Level III, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.",
author = "Nawabi, {Danyal H.} and Stephanie Gold and Steven Lyman and Kara Fields and Padgett, {Douglas E.} and Potter, {Hollis G.}",
year = "2014",
month = "2",
doi = "10.1007/s11999-013-2788-y",
language = "English",
volume = "472",
pages = "471--481",
journal = "Clinical Orthopaedics and Related Research",
issn = "0009-921X",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - MRI predicts ALVAL and tissue damage in metal-on-metal hip arthroplasty

AU - Nawabi, Danyal H.

AU - Gold, Stephanie

AU - Lyman, Steven

AU - Fields, Kara

AU - Padgett, Douglas E.

AU - Potter, Hollis G.

PY - 2014/2

Y1 - 2014/2

N2 - Background: Adverse local tissue reactions (ALTR) around metal-on-metal (MOM) hip arthroplasties are increasingly being recognized as a cause of failure. These reactions may be associated with intraoperative tissue damage and complication rates as high as 50% after revision. Although MRI can identify ALTR in MOM hips, it is unclear whether the MRI findings predict those at revision surgery. Questions/purposes: We therefore (1) identified which MRI characteristics correlated with histologically confirmed ALTR (using the aseptic lymphocytic vasculitis-associated lesions [ALVAL] score) and intraoperative tissue damage and (2) developed a predictive model using modified MRI to detect ALVAL and quantify intraoperative tissue damage. Methods: We retrospectively reviewed 68 patients with failed MOM hip arthroplasties who underwent preoperative MRI and subsequent revision surgery. Images were analyzed to determine synovial volume, osteolysis, and synovial thickness. The ALVAL score was used to grade tissue samples, thus identifying a subset of patients with ALTR. Intraoperative tissue damage was graded using a four-point scale. Random forest analysis determined the sensitivity and specificity of MRI characteristics in detecting ALVAL (score ≥ 5) and intraoperative tissue damage. Results: Maximal synovial thicknesses and synovial volumes as determined on MRI correlated with the ALVAL score and were higher in cases of severe intraoperative tissue damage. Our MRI predictive model showed sensitivity and specificity of 94% and 87%, respectively, for detecting ALVAL and 90% and 86%, respectively, for quantifying intraoperative tissue damage. Conclusions: MRI is sensitive and specific in detecting ALVAL and tissue damage in patients with MOM hip implants. MRI can be used as a screening tool to guide surgeons toward timely revision surgery. Level of Evidence: Level III, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.

AB - Background: Adverse local tissue reactions (ALTR) around metal-on-metal (MOM) hip arthroplasties are increasingly being recognized as a cause of failure. These reactions may be associated with intraoperative tissue damage and complication rates as high as 50% after revision. Although MRI can identify ALTR in MOM hips, it is unclear whether the MRI findings predict those at revision surgery. Questions/purposes: We therefore (1) identified which MRI characteristics correlated with histologically confirmed ALTR (using the aseptic lymphocytic vasculitis-associated lesions [ALVAL] score) and intraoperative tissue damage and (2) developed a predictive model using modified MRI to detect ALVAL and quantify intraoperative tissue damage. Methods: We retrospectively reviewed 68 patients with failed MOM hip arthroplasties who underwent preoperative MRI and subsequent revision surgery. Images were analyzed to determine synovial volume, osteolysis, and synovial thickness. The ALVAL score was used to grade tissue samples, thus identifying a subset of patients with ALTR. Intraoperative tissue damage was graded using a four-point scale. Random forest analysis determined the sensitivity and specificity of MRI characteristics in detecting ALVAL (score ≥ 5) and intraoperative tissue damage. Results: Maximal synovial thicknesses and synovial volumes as determined on MRI correlated with the ALVAL score and were higher in cases of severe intraoperative tissue damage. Our MRI predictive model showed sensitivity and specificity of 94% and 87%, respectively, for detecting ALVAL and 90% and 86%, respectively, for quantifying intraoperative tissue damage. Conclusions: MRI is sensitive and specific in detecting ALVAL and tissue damage in patients with MOM hip implants. MRI can be used as a screening tool to guide surgeons toward timely revision surgery. Level of Evidence: Level III, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.

UR - http://www.scopus.com/inward/record.url?scp=84893682758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893682758&partnerID=8YFLogxK

U2 - 10.1007/s11999-013-2788-y

DO - 10.1007/s11999-013-2788-y

M3 - Article

C2 - 23354460

AN - SCOPUS:84893682758

VL - 472

SP - 471

EP - 481

JO - Clinical Orthopaedics and Related Research

JF - Clinical Orthopaedics and Related Research

SN - 0009-921X

IS - 2

ER -