mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Yurika Mizobe, Daichi Oikawa, Shoichiro Tsuyama, Yoriko Akimoto, Kousuke Hamasu, Eiichiro Onitsuka, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

Original languageEnglish
Pages (from-to)3067-3070
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number11
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

Matrix Metalloproteinase 12
Protein-Lysine 6-Oxidase
Elastic Tissue
Skin
Messenger RNA
Fibers
Elasticity
Desmosine
Light
Dermis
Matrix Metalloproteinases
Crosslinking
Enzymes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin. / Mizobe, Yurika; Oikawa, Daichi; Tsuyama, Shoichiro; Akimoto, Yoriko; Hamasu, Kousuke; Onitsuka, Eiichiro; Sato, Mikako; Takahata, Yoshihisa; Morimatsu, Fumiki; Furuse, Mitsuhiro.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 11, 01.12.2008, p. 3067-3070.

Research output: Contribution to journalArticle

Mizobe, Y, Oikawa, D, Tsuyama, S, Akimoto, Y, Hamasu, K, Onitsuka, E, Sato, M, Takahata, Y, Morimatsu, F & Furuse, M 2008, 'mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin', Bioscience, Biotechnology and Biochemistry, vol. 72, no. 11, pp. 3067-3070. https://doi.org/10.1271/bbb.80450
Mizobe Y, Oikawa D, Tsuyama S, Akimoto Y, Hamasu K, Onitsuka E et al. mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin. Bioscience, Biotechnology and Biochemistry. 2008 Dec 1;72(11):3067-3070. https://doi.org/10.1271/bbb.80450
Mizobe, Yurika ; Oikawa, Daichi ; Tsuyama, Shoichiro ; Akimoto, Yoriko ; Hamasu, Kousuke ; Onitsuka, Eiichiro ; Sato, Mikako ; Takahata, Yoshihisa ; Morimatsu, Fumiki ; Furuse, Mitsuhiro. / mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin. In: Bioscience, Biotechnology and Biochemistry. 2008 ; Vol. 72, No. 11. pp. 3067-3070.
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