TY - JOUR
T1 - Mucinous cystic tumor of the pancreas
T2 - Immunohistochemical assessment of 'ovarian-type stroma'
AU - Izumo, Akihiko
AU - Yamaguchi, Koji
AU - Eguchi, Takashi
AU - Nishiyama, Ken Ichi
AU - Yamamoto, Hidetaka
AU - Yonemasu, Hirotoshi
AU - Yao, Takashi
AU - Tanaka, Masao
AU - Tsuneyoshi, Masazumi
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2003/5
Y1 - 2003/5
N2 - The new histopathological classification of exocrine pancreatic tumors by the World Health Organization, now includes 'ovarian-type stroma' ('OS') in the definition of mucinous cystic tumor of the pancreas (MCT-P). This study investigated the clinicopathological findings of the MCT-P according to WHO classification and scrutinize the function of 'OS' in MCT-P immunohistochemically. Thirty-four cases of MCT-P (28 adenomas, 2 borderline tumors and 4 adenocarcinomas) were examined clinicopathologically. The 'OS' of 34 MCTs-P were studied immunohistochemically and compared with the stroma of 10 mucinous cystic tumors of the ovary (MCTs-O), 10 conventional pancreatic carcinomas and 6 normal ovaries. Almost all 34 MCTs-P were located in the body-tail of the pancreas of middle-aged women. Histologically the 'OS' cells exhibited luteinization in 11/34 (32.4%). Immunohistochemically, both 'OS' cells and the stromal cells in MCT-O showed similar positivity rates; calponin (34/34 and 9/10), h-caldesmon (28/34 and 8/10), α-inhibin (29/34 and 9/10), estrogen-receptor (21/34 and 6/10) and progesterone-receptor (28/34 and 9/10, respectively). Some neoplastic epithelial cells of MCT-P were positive for human chorionic gonadotropin (hCG) (21/34, 61.8%). This study indicates the predominance of MCT in the distal pancreas of middle-aged women. Furthermore, the immunohistochemical and histological results demonstrate that the 'OS' of MCT-P and the stroma of MCT-O share the same characteristics. The results also suggested that the hCG produced by the neoplastic epithelium probably plays an important role in the luteinization of the stroma of MCT-P. We therefore conclude there is a possibility that MCT-P originates from the left remnant primordial gonadal cells which migrated to the pancreatic anlage during the early development of the fetus.
AB - The new histopathological classification of exocrine pancreatic tumors by the World Health Organization, now includes 'ovarian-type stroma' ('OS') in the definition of mucinous cystic tumor of the pancreas (MCT-P). This study investigated the clinicopathological findings of the MCT-P according to WHO classification and scrutinize the function of 'OS' in MCT-P immunohistochemically. Thirty-four cases of MCT-P (28 adenomas, 2 borderline tumors and 4 adenocarcinomas) were examined clinicopathologically. The 'OS' of 34 MCTs-P were studied immunohistochemically and compared with the stroma of 10 mucinous cystic tumors of the ovary (MCTs-O), 10 conventional pancreatic carcinomas and 6 normal ovaries. Almost all 34 MCTs-P were located in the body-tail of the pancreas of middle-aged women. Histologically the 'OS' cells exhibited luteinization in 11/34 (32.4%). Immunohistochemically, both 'OS' cells and the stromal cells in MCT-O showed similar positivity rates; calponin (34/34 and 9/10), h-caldesmon (28/34 and 8/10), α-inhibin (29/34 and 9/10), estrogen-receptor (21/34 and 6/10) and progesterone-receptor (28/34 and 9/10, respectively). Some neoplastic epithelial cells of MCT-P were positive for human chorionic gonadotropin (hCG) (21/34, 61.8%). This study indicates the predominance of MCT in the distal pancreas of middle-aged women. Furthermore, the immunohistochemical and histological results demonstrate that the 'OS' of MCT-P and the stroma of MCT-O share the same characteristics. The results also suggested that the hCG produced by the neoplastic epithelium probably plays an important role in the luteinization of the stroma of MCT-P. We therefore conclude there is a possibility that MCT-P originates from the left remnant primordial gonadal cells which migrated to the pancreatic anlage during the early development of the fetus.
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M3 - Article
C2 - 12684617
AN - SCOPUS:0642283923
VL - 10
SP - 515
EP - 525
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 3
ER -