Bacillus amyloliquefaciens strain RC-2 produced seven antifungal compounds (1-7) secreted into the culture filtrate. These compounds inhibited the development of mulberry anthracnose caused by the fungus, Colletotrichum dematium. Chemical structural analyses by NMR and FAB-MS revealed that all these compounds were iturins (cyclic peptides with the following sequence: L-Asn → D-Tyr → D-Asn → L-Gln → L-Pro → D-Asn → L-Ser → D-β-amino acid →) and compounds 1-6 are identical to iturins A-2-A-7, respectively. Compound 7 (iturin A-8) is a new iturin, which has a -(CH2)10CH(CH3)CH2CH3 group as a side chain in the β-amino acid in the molecule.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Plant Science