Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching

Masafumi Nakamura, Go Wakabayashi, Yoshihiro Miyasaka, Masao Tanaka, Takanori Morikawa, Michiaki Unno, Hiroshi Tajima, Yusuke Kumamoto, Sohei Satoi, Masanori Kwon, Hirochika Toyama, Yonson Ku, Hideyuki Yoshitomi, Satoshi Nara, Kazuaki Shimada, Takahide Yokoyama, Shinichi Miyagawa, Yoichi Toyama, Katsuhiko Yanaga, Tsutomu FujiiYasuhiro Kodera, Yasuyuki Tomiyama, Hiroaki Miyata, Takeshi Takahara, Toru Beppu, Hiroki Yamaue, Masaru Miyazaki, Tadahiro Takada

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background Laparoscopic distal pancreatectomy has been shown to be associated with favorable postoperative outcomes using meta-analysis. However, there have been no randomized controlled studies yet. This study aimed to compare laparoscopic and open distal pancreatectomy using propensity score-matching. Methods We retrospectively collected perioperative data of 2,266 patients who underwent distal pancreatectomy in 69 institutes from 2006-2013 in Japan. Among them, 2,010 patients were enrolled in this study and divided into two groups, laparoscopic distal pancreatectomy and open distal pancreatectomy. Perioperative outcomes were compared between the groups using unmatched and propensity matched analysis. Results After propensity score-matching, laparoscopic distal pancreatectomy was associated with favorable perioperative outcomes compared with open distal pancreatectomy, including higher rate of preservation of spleen and splenic vessels (P < 0.001); lower rates of intraoperative transfusion (P = 0.020), clinical grade of pancreatic fistula (International Study Group on Pancreatic Fistula grade B and C; P < 0.001), and morbidity (P < 0.001); and shorter hospital stay (P = 0.001), but a longer operative time (P < 0.001). Conclusions Laparoscopic distal pancreatectomy was associated with more favorable perioperative outcomes than open distal pancreatectomy. Nakamura and colleagues conducted the largest multicenter propensity score matched study to date comparing laparoscopic and open distal pancreatectomy, based on data from 2,266 patients. The laparoscopic procedure was associated with significantly more favorable short-term postoperative outcomes than open surgery, particularly in terms of morbidity and development of pancreatic fistulas.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

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Propensity Score
Pancreatectomy
Multicenter Studies
Pancreatic Fistula
Morbidity
Operative Time
Meta-Analysis
Length of Stay
Japan
Spleen

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. / Nakamura, Masafumi; Wakabayashi, Go; Miyasaka, Yoshihiro; Tanaka, Masao; Morikawa, Takanori; Unno, Michiaki; Tajima, Hiroshi; Kumamoto, Yusuke; Satoi, Sohei; Kwon, Masanori; Toyama, Hirochika; Ku, Yonson; Yoshitomi, Hideyuki; Nara, Satoshi; Shimada, Kazuaki; Yokoyama, Takahide; Miyagawa, Shinichi; Toyama, Yoichi; Yanaga, Katsuhiko; Fujii, Tsutomu; Kodera, Yasuhiro; Tomiyama, Yasuyuki; Miyata, Hiroaki; Takahara, Takeshi; Beppu, Toru; Yamaue, Hiroki; Miyazaki, Masaru; Takada, Tadahiro.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 22, No. 10, 01.10.2015, p. 731-736.

Research output: Contribution to journalArticle

Nakamura, M, Wakabayashi, G, Miyasaka, Y, Tanaka, M, Morikawa, T, Unno, M, Tajima, H, Kumamoto, Y, Satoi, S, Kwon, M, Toyama, H, Ku, Y, Yoshitomi, H, Nara, S, Shimada, K, Yokoyama, T, Miyagawa, S, Toyama, Y, Yanaga, K, Fujii, T, Kodera, Y, Tomiyama, Y, Miyata, H, Takahara, T, Beppu, T, Yamaue, H, Miyazaki, M & Takada, T 2015, 'Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 22, no. 10, pp. 731-736. https://doi.org/10.1002/jhbp.268
Nakamura, Masafumi ; Wakabayashi, Go ; Miyasaka, Yoshihiro ; Tanaka, Masao ; Morikawa, Takanori ; Unno, Michiaki ; Tajima, Hiroshi ; Kumamoto, Yusuke ; Satoi, Sohei ; Kwon, Masanori ; Toyama, Hirochika ; Ku, Yonson ; Yoshitomi, Hideyuki ; Nara, Satoshi ; Shimada, Kazuaki ; Yokoyama, Takahide ; Miyagawa, Shinichi ; Toyama, Yoichi ; Yanaga, Katsuhiko ; Fujii, Tsutomu ; Kodera, Yasuhiro ; Tomiyama, Yasuyuki ; Miyata, Hiroaki ; Takahara, Takeshi ; Beppu, Toru ; Yamaue, Hiroki ; Miyazaki, Masaru ; Takada, Tadahiro. / Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2015 ; Vol. 22, No. 10. pp. 731-736.
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abstract = "Background Laparoscopic distal pancreatectomy has been shown to be associated with favorable postoperative outcomes using meta-analysis. However, there have been no randomized controlled studies yet. This study aimed to compare laparoscopic and open distal pancreatectomy using propensity score-matching. Methods We retrospectively collected perioperative data of 2,266 patients who underwent distal pancreatectomy in 69 institutes from 2006-2013 in Japan. Among them, 2,010 patients were enrolled in this study and divided into two groups, laparoscopic distal pancreatectomy and open distal pancreatectomy. Perioperative outcomes were compared between the groups using unmatched and propensity matched analysis. Results After propensity score-matching, laparoscopic distal pancreatectomy was associated with favorable perioperative outcomes compared with open distal pancreatectomy, including higher rate of preservation of spleen and splenic vessels (P < 0.001); lower rates of intraoperative transfusion (P = 0.020), clinical grade of pancreatic fistula (International Study Group on Pancreatic Fistula grade B and C; P < 0.001), and morbidity (P < 0.001); and shorter hospital stay (P = 0.001), but a longer operative time (P < 0.001). Conclusions Laparoscopic distal pancreatectomy was associated with more favorable perioperative outcomes than open distal pancreatectomy. Nakamura and colleagues conducted the largest multicenter propensity score matched study to date comparing laparoscopic and open distal pancreatectomy, based on data from 2,266 patients. The laparoscopic procedure was associated with significantly more favorable short-term postoperative outcomes than open surgery, particularly in terms of morbidity and development of pancreatic fistulas.",
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T1 - Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching

AU - Nakamura, Masafumi

AU - Wakabayashi, Go

AU - Miyasaka, Yoshihiro

AU - Tanaka, Masao

AU - Morikawa, Takanori

AU - Unno, Michiaki

AU - Tajima, Hiroshi

AU - Kumamoto, Yusuke

AU - Satoi, Sohei

AU - Kwon, Masanori

AU - Toyama, Hirochika

AU - Ku, Yonson

AU - Yoshitomi, Hideyuki

AU - Nara, Satoshi

AU - Shimada, Kazuaki

AU - Yokoyama, Takahide

AU - Miyagawa, Shinichi

AU - Toyama, Yoichi

AU - Yanaga, Katsuhiko

AU - Fujii, Tsutomu

AU - Kodera, Yasuhiro

AU - Tomiyama, Yasuyuki

AU - Miyata, Hiroaki

AU - Takahara, Takeshi

AU - Beppu, Toru

AU - Yamaue, Hiroki

AU - Miyazaki, Masaru

AU - Takada, Tadahiro

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background Laparoscopic distal pancreatectomy has been shown to be associated with favorable postoperative outcomes using meta-analysis. However, there have been no randomized controlled studies yet. This study aimed to compare laparoscopic and open distal pancreatectomy using propensity score-matching. Methods We retrospectively collected perioperative data of 2,266 patients who underwent distal pancreatectomy in 69 institutes from 2006-2013 in Japan. Among them, 2,010 patients were enrolled in this study and divided into two groups, laparoscopic distal pancreatectomy and open distal pancreatectomy. Perioperative outcomes were compared between the groups using unmatched and propensity matched analysis. Results After propensity score-matching, laparoscopic distal pancreatectomy was associated with favorable perioperative outcomes compared with open distal pancreatectomy, including higher rate of preservation of spleen and splenic vessels (P < 0.001); lower rates of intraoperative transfusion (P = 0.020), clinical grade of pancreatic fistula (International Study Group on Pancreatic Fistula grade B and C; P < 0.001), and morbidity (P < 0.001); and shorter hospital stay (P = 0.001), but a longer operative time (P < 0.001). Conclusions Laparoscopic distal pancreatectomy was associated with more favorable perioperative outcomes than open distal pancreatectomy. Nakamura and colleagues conducted the largest multicenter propensity score matched study to date comparing laparoscopic and open distal pancreatectomy, based on data from 2,266 patients. The laparoscopic procedure was associated with significantly more favorable short-term postoperative outcomes than open surgery, particularly in terms of morbidity and development of pancreatic fistulas.

AB - Background Laparoscopic distal pancreatectomy has been shown to be associated with favorable postoperative outcomes using meta-analysis. However, there have been no randomized controlled studies yet. This study aimed to compare laparoscopic and open distal pancreatectomy using propensity score-matching. Methods We retrospectively collected perioperative data of 2,266 patients who underwent distal pancreatectomy in 69 institutes from 2006-2013 in Japan. Among them, 2,010 patients were enrolled in this study and divided into two groups, laparoscopic distal pancreatectomy and open distal pancreatectomy. Perioperative outcomes were compared between the groups using unmatched and propensity matched analysis. Results After propensity score-matching, laparoscopic distal pancreatectomy was associated with favorable perioperative outcomes compared with open distal pancreatectomy, including higher rate of preservation of spleen and splenic vessels (P < 0.001); lower rates of intraoperative transfusion (P = 0.020), clinical grade of pancreatic fistula (International Study Group on Pancreatic Fistula grade B and C; P < 0.001), and morbidity (P < 0.001); and shorter hospital stay (P = 0.001), but a longer operative time (P < 0.001). Conclusions Laparoscopic distal pancreatectomy was associated with more favorable perioperative outcomes than open distal pancreatectomy. Nakamura and colleagues conducted the largest multicenter propensity score matched study to date comparing laparoscopic and open distal pancreatectomy, based on data from 2,266 patients. The laparoscopic procedure was associated with significantly more favorable short-term postoperative outcomes than open surgery, particularly in terms of morbidity and development of pancreatic fistulas.

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