Multicenter study of early pancreatic cancer in Japan

for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC)

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background/Objectives: The diagnosis of early-stage pancreatic ductal adenocarcinoma (PDAC) is still challenging. We conducted a multicenter study to clarify the clinical features of early-stage PDAC in Japan. Methods: We collected patients with stage 0 and stage I PDAC according to the sixth edition of the Japanese Classification of Pancreatic Carcinoma. We retrospectively analyzed the clinical profiles including opportunities for medical examination, imaging modalities and findings, methods of cytological diagnosis, and prognosis according to the stages at diagnosis. Results: Two hundred cases with Stage 0 and stage I PDAC were reported from 14 institutions, which accounted for approximately 0.7% and 3% of all PDAC cases, respectively. Overall, 20% of the early-stage PDAC cases were symptomatic. Indirect imaging findings such as dilatation of the main pancreatic duct were useful to detect early-stage PDAC. In particular, local fatty changes may be specific to early-stage PDAC. For preoperative pathologic diagnosis, cytology during endoscopic retrograde cholangiopancreatography was more commonly applied than endoscopic ultrasound fine-needle aspiration. Although the overall prognosis was favorable, new PDAC lesions developed in the remnant pancreas in 11.5% cases. Conclusions: This multicenter study revealed several key points concerning the diagnosis and management of early-stage PDAC, including screening of asymptomatic cases, importance of indirect imaging findings, application of cytology during endoscopic retrograde cholangiopancreatography, and the risk of carcinogenesis in the remnant pancreas.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalPancreatology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2018

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Pancreatic Neoplasms
Multicenter Studies
Japan
Adenocarcinoma
Endoscopic Retrograde Cholangiopancreatography
Cell Biology
Pancreas
Pancreatic Ducts
Diagnostic Imaging
Fine Needle Biopsy
Dilatation
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC) (2018). Multicenter study of early pancreatic cancer in Japan. Pancreatology, 18(1), 61-67. https://doi.org/10.1016/j.pan.2017.11.007

Multicenter study of early pancreatic cancer in Japan. / for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC).

In: Pancreatology, Vol. 18, No. 1, 01.2018, p. 61-67.

Research output: Contribution to journalArticle

for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC) 2018, 'Multicenter study of early pancreatic cancer in Japan', Pancreatology, vol. 18, no. 1, pp. 61-67. https://doi.org/10.1016/j.pan.2017.11.007
for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC). Multicenter study of early pancreatic cancer in Japan. Pancreatology. 2018 Jan;18(1):61-67. https://doi.org/10.1016/j.pan.2017.11.007
for the Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC). / Multicenter study of early pancreatic cancer in Japan. In: Pancreatology. 2018 ; Vol. 18, No. 1. pp. 61-67.
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abstract = "Background/Objectives: The diagnosis of early-stage pancreatic ductal adenocarcinoma (PDAC) is still challenging. We conducted a multicenter study to clarify the clinical features of early-stage PDAC in Japan. Methods: We collected patients with stage 0 and stage I PDAC according to the sixth edition of the Japanese Classification of Pancreatic Carcinoma. We retrospectively analyzed the clinical profiles including opportunities for medical examination, imaging modalities and findings, methods of cytological diagnosis, and prognosis according to the stages at diagnosis. Results: Two hundred cases with Stage 0 and stage I PDAC were reported from 14 institutions, which accounted for approximately 0.7{\%} and 3{\%} of all PDAC cases, respectively. Overall, 20{\%} of the early-stage PDAC cases were symptomatic. Indirect imaging findings such as dilatation of the main pancreatic duct were useful to detect early-stage PDAC. In particular, local fatty changes may be specific to early-stage PDAC. For preoperative pathologic diagnosis, cytology during endoscopic retrograde cholangiopancreatography was more commonly applied than endoscopic ultrasound fine-needle aspiration. Although the overall prognosis was favorable, new PDAC lesions developed in the remnant pancreas in 11.5{\%} cases. Conclusions: This multicenter study revealed several key points concerning the diagnosis and management of early-stage PDAC, including screening of asymptomatic cases, importance of indirect imaging findings, application of cytology during endoscopic retrograde cholangiopancreatography, and the risk of carcinogenesis in the remnant pancreas.",
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AU - Kanno, Atsushi

AU - Masamune, Atsushi

AU - Hanada, Keiji

AU - Maguchi, Hiroyuki

AU - Shimizu, Yasuhiro

AU - Ueki, Toshiharu

AU - Hasebe, Osamu

AU - Ohtsuka, Takao

AU - Nakamura, Masafumi

AU - Takenaka, Mamoru

AU - Kitano, Masayuki

AU - Kikuyama, Masataka

AU - Gabata, Toshifumi

AU - Yoshida, Koji

AU - Sasaki, Tamito

AU - Serikawa, Masahiro

AU - Furukawa, Toru

AU - Yanagisawa, Akio

AU - Shimosegawa, Tooru

PY - 2018/1

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N2 - Background/Objectives: The diagnosis of early-stage pancreatic ductal adenocarcinoma (PDAC) is still challenging. We conducted a multicenter study to clarify the clinical features of early-stage PDAC in Japan. Methods: We collected patients with stage 0 and stage I PDAC according to the sixth edition of the Japanese Classification of Pancreatic Carcinoma. We retrospectively analyzed the clinical profiles including opportunities for medical examination, imaging modalities and findings, methods of cytological diagnosis, and prognosis according to the stages at diagnosis. Results: Two hundred cases with Stage 0 and stage I PDAC were reported from 14 institutions, which accounted for approximately 0.7% and 3% of all PDAC cases, respectively. Overall, 20% of the early-stage PDAC cases were symptomatic. Indirect imaging findings such as dilatation of the main pancreatic duct were useful to detect early-stage PDAC. In particular, local fatty changes may be specific to early-stage PDAC. For preoperative pathologic diagnosis, cytology during endoscopic retrograde cholangiopancreatography was more commonly applied than endoscopic ultrasound fine-needle aspiration. Although the overall prognosis was favorable, new PDAC lesions developed in the remnant pancreas in 11.5% cases. Conclusions: This multicenter study revealed several key points concerning the diagnosis and management of early-stage PDAC, including screening of asymptomatic cases, importance of indirect imaging findings, application of cytology during endoscopic retrograde cholangiopancreatography, and the risk of carcinogenesis in the remnant pancreas.

AB - Background/Objectives: The diagnosis of early-stage pancreatic ductal adenocarcinoma (PDAC) is still challenging. We conducted a multicenter study to clarify the clinical features of early-stage PDAC in Japan. Methods: We collected patients with stage 0 and stage I PDAC according to the sixth edition of the Japanese Classification of Pancreatic Carcinoma. We retrospectively analyzed the clinical profiles including opportunities for medical examination, imaging modalities and findings, methods of cytological diagnosis, and prognosis according to the stages at diagnosis. Results: Two hundred cases with Stage 0 and stage I PDAC were reported from 14 institutions, which accounted for approximately 0.7% and 3% of all PDAC cases, respectively. Overall, 20% of the early-stage PDAC cases were symptomatic. Indirect imaging findings such as dilatation of the main pancreatic duct were useful to detect early-stage PDAC. In particular, local fatty changes may be specific to early-stage PDAC. For preoperative pathologic diagnosis, cytology during endoscopic retrograde cholangiopancreatography was more commonly applied than endoscopic ultrasound fine-needle aspiration. Although the overall prognosis was favorable, new PDAC lesions developed in the remnant pancreas in 11.5% cases. Conclusions: This multicenter study revealed several key points concerning the diagnosis and management of early-stage PDAC, including screening of asymptomatic cases, importance of indirect imaging findings, application of cytology during endoscopic retrograde cholangiopancreatography, and the risk of carcinogenesis in the remnant pancreas.

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