Multicentric papillary renal cell carcinoma associated with renal adenomatosis

Keijiro Kiyoshima, Yoshinao Oda, Toshihiko Nakamura, Toshiro Migita, Koji Okumura, Seiji Naito, Masazumi Tsuneyoshi

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Abstract

A case of multicentric papillary renal cell carcinoma (RCC) associated with renal adenomatosis in the bilateral kidneys is reported. Bilateral multiple renal cysts in a 46-year-old man were pointed out incidentally by ultrasonography. Some of the left renal lesions were considered to be RCC, and left radical nephrectomy was performed accordingly. The left kidney was occupied by numerous solid nodules, which ranged from yellow to tan in color, and some of the large ones had foci of hemorrhage and necrosis. Microscopically, most of the tumors showed papillary RCC associated with renal adenoma, while others consisted only of adenomas. Ten months later, multiple lesions of the right kidney, which were initially considered to be multiple cysts, were found to have become enlarged and some of them were diagnosed as RCC. Thus, right radical nephrectomy was also performed, and these tumors showed the same features as the left renal tumors. The patient's familial history was not remarkable. The kidneys revealed various histological features, ranging from dysplastic to adenoma or carcinoma, including transitional or overlapping features between them. The findings suggest an adenoma-carcinoma sequence in papillary RCC. It is worth considering such entities.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalPathology International
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 1 2004

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Renal Cell Carcinoma
Kidney
Adenoma
Nephrectomy
Cysts
Carcinoma
Neoplasms
Ultrasonography
Necrosis
Color
History
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kiyoshima, K., Oda, Y., Nakamura, T., Migita, T., Okumura, K., Naito, S., & Tsuneyoshi, M. (2004). Multicentric papillary renal cell carcinoma associated with renal adenomatosis. Pathology International, 54(4), 266-272. https://doi.org/10.1111/j.1440-1827.2004.01618.x

Multicentric papillary renal cell carcinoma associated with renal adenomatosis. / Kiyoshima, Keijiro; Oda, Yoshinao; Nakamura, Toshihiko; Migita, Toshiro; Okumura, Koji; Naito, Seiji; Tsuneyoshi, Masazumi.

In: Pathology International, Vol. 54, No. 4, 01.04.2004, p. 266-272.

Research output: Contribution to journalArticle

Kiyoshima, K, Oda, Y, Nakamura, T, Migita, T, Okumura, K, Naito, S & Tsuneyoshi, M 2004, 'Multicentric papillary renal cell carcinoma associated with renal adenomatosis', Pathology International, vol. 54, no. 4, pp. 266-272. https://doi.org/10.1111/j.1440-1827.2004.01618.x
Kiyoshima, Keijiro ; Oda, Yoshinao ; Nakamura, Toshihiko ; Migita, Toshiro ; Okumura, Koji ; Naito, Seiji ; Tsuneyoshi, Masazumi. / Multicentric papillary renal cell carcinoma associated with renal adenomatosis. In: Pathology International. 2004 ; Vol. 54, No. 4. pp. 266-272.
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