Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Kazuma Tsuboi, Shinya Fukuba, Ryo Naraoka, Katsuhiko Fujita, Kotaro Kajikawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

Original languageEnglish
Pages (from-to)4486-4490
Number of pages5
JournalApplied Optics
Volume46
Issue number20
DOIs
Publication statusPublished - Jul 10 2007

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Nanospheres
platforms
Gold
gold
Imaging techniques
Self assembled monolayers
Harmonic generation
chutes
Labels
harmonic generations
rays
reflectance
Glass
glass

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging. / Tsuboi, Kazuma; Fukuba, Shinya; Naraoka, Ryo; Fujita, Katsuhiko; Kajikawa, Kotaro.

In: Applied Optics, Vol. 46, No. 20, 10.07.2007, p. 4486-4490.

Research output: Contribution to journalArticle

Tsuboi, Kazuma ; Fukuba, Shinya ; Naraoka, Ryo ; Fujita, Katsuhiko ; Kajikawa, Kotaro. / Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging. In: Applied Optics. 2007 ; Vol. 46, No. 20. pp. 4486-4490.
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