Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging

Kazuma Tsuboi, Shinya Fukuba, Ryo Naraoka, Katsuhiko Fujita, Kotaro Kajikawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

Original languageEnglish
Pages (from-to)4486-4490
Number of pages5
JournalApplied Optics
Volume46
Issue number20
DOIs
Publication statusPublished - Jul 10 2007

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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