Multidrug resistance-associated protein subfamily transporters and drug resistance

Michihiko Kuwano, Satoshi Toh, Takeshi Uchiumi, Hiroshi Takano, Kimitoshi Kohno, Morimasa Wada

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Mutidrug resistance-associated protein gene MRP/MRP1, and its family genes, including MRP2/cMOAT, have been isolated and characterized. These ATP-binding cassette (ABC) super-family transporter genes are differentially expressed in various normal tissues and multidrug-resistant cell lines. Transfection of MRP/MRP1 and MRP2/cMOAT cDNA confers drug resistance on different spectra of anticancer agents from that of MDR1 coding P-glycoprotein. Although it remains unclear how MRP/MRP1 and related family genes are specifically involved in drug resistance in clinical cancers, current knowledge of the MRP subfamily suggests the importance of this class of transporters as a molecular target for drug sensitivity to anticancer agents.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalAnti-Cancer Drug Design
Volume14
Issue number2
Publication statusPublished - Apr 1 1999

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Kuwano, M., Toh, S., Uchiumi, T., Takano, H., Kohno, K., & Wada, M. (1999). Multidrug resistance-associated protein subfamily transporters and drug resistance. Anti-Cancer Drug Design, 14(2), 123-131.