Multifocal metanephric adenoma in childhood

Kenichi Kouhashi, Yoshinao Oda, Mari Nakamori, Hidetaka Yamamoto, Sadafumi Tamiya, Taro Toubo, Yoshiaki Kinoshita, Tatsuro Tajiri, Tomoaki Taguchi, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

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Abstract

Metanephric adenoma is the most commonly occurring member of the metanephric tumor family, which also includes metanephric adenofibroma and metanephric stromal tumor. According to the World Health Organization classification, however, it is not commonly multifocal. Reported herein is the case of a 9-year-old boy with multifocal metanephric adenoma. Histologically, surgical sections showed multifocal proliferation of small rounded and uniform cells with smooth nuclear contours, scant pale-staining cytoplasm, dark-staining nuclei, and inconspicuous nucleoli: the cells were arranged in sheets and acinal, ductal, glomeruloid, and papillary structures. On immunohistochemistry the tumor cells were positive for vimentin, cytokeratins (CAM5.2, AE1/AE3, and CK18), and WT1, but negative for cytokeratin 7 (CK7) and epithelial membrane antigen (EMA). The Ki-67 labeling index was <1%. In addition, cytogenetic analysis indicated a normal karyotype (46XY). Other histologically similar tumors are papillary renal cell carcinoma and nephroblastoma, and it is necessary to distinguish metanephric adenoma from those tumors because of malignancy. In contrast to those tumors, metanephric adenoma has inconspicuous nucleoli, loss of CK7 and EMA expression, and no mitotic figures. Thus, the histological and immunohistochemical features of the present case were compatible with metanephric adenoma.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalPathology International
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

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Adenoma
Neoplasms
Keratin-7
Mucin-1
Adenofibroma
Cell Nucleolus
Staining and Labeling
Wilms Tumor
Cytogenetic Analysis
Vimentin
Keratins
Karyotype
Renal Cell Carcinoma
Cytoplasm
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Multifocal metanephric adenoma in childhood. / Kouhashi, Kenichi; Oda, Yoshinao; Nakamori, Mari; Yamamoto, Hidetaka; Tamiya, Sadafumi; Toubo, Taro; Kinoshita, Yoshiaki; Tajiri, Tatsuro; Taguchi, Tomoaki; Tsuneyoshi, Masazumi.

In: Pathology International, Vol. 59, No. 1, 01.01.2009, p. 49-52.

Research output: Contribution to journalArticle

Kouhashi, K, Oda, Y, Nakamori, M, Yamamoto, H, Tamiya, S, Toubo, T, Kinoshita, Y, Tajiri, T, Taguchi, T & Tsuneyoshi, M 2009, 'Multifocal metanephric adenoma in childhood', Pathology International, vol. 59, no. 1, pp. 49-52. https://doi.org/10.1111/j.1440-1827.2008.02324.x
Kouhashi, Kenichi ; Oda, Yoshinao ; Nakamori, Mari ; Yamamoto, Hidetaka ; Tamiya, Sadafumi ; Toubo, Taro ; Kinoshita, Yoshiaki ; Tajiri, Tatsuro ; Taguchi, Tomoaki ; Tsuneyoshi, Masazumi. / Multifocal metanephric adenoma in childhood. In: Pathology International. 2009 ; Vol. 59, No. 1. pp. 49-52.
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