Multifunctional effects of bradykinin on glial cells in relation to potential anti-inflammatory effects

Mami Noda, Kenjiro Sasaki, Masataka Ifuku, Keiji Wada

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


Kinins have been reported to be produced and act at the site of injury and inflammation. Despite many reports that they are likely to initiate a particular cascade of inflammatory events, bradykinin (BK) has anti-inflammatory effects in the brain mediated by glial cells. In the present review, we have attempted to describe the complex responses and immediate reaction of glial cells to BK. Glial cells express BK receptors and induce Ca2+-dependent signal cascades. Among them, production of prostaglandin E2 (PGE2), via B1 receptors in primary cultured microglia, has a negative feedback effect on lipopolysaccharide (LPS)-induced release of tumor necrosis factor-α (TNF-α) via increasing intracellular cyclic adenosine monophosphate (cAMP). In addition, BK up-regulates the production of neurotrophic factors such as nerve growth factor (NGF) via B2 receptors in astrocytes. These results suggest that BK may have anti-inflammatory and neuroprotective effects in the brain through multiple functions on glial cells. These observations may help to understand the paradox on the role of kinins in the central nervous system and may be useful for therapeutic strategy.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalNeurochemistry International
Issue number2-4 SPEC. ISS.
Publication statusPublished - Jul 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology


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