Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis

Akiko Kukita, Toshio Kukita

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its receptor RANK. Recent reports demonstrate that RANKL has important roles in organogenesis stimulating proliferation and differentiation of epithelial and stroma cells. RANKL is induced not only by cytokines and hormones but also by UV-irradiation, inflammation and carcinogens. Expression of RANK and RANKL is found in several human cancer cell lines, and RANK signaling stimulates proliferation, migration and epithelial-mesenchymal transition of cancer cells, which may be involved in metastasis via an autocrine/paracrine mechanism. RANKL regulates the number of Tregs that produce RANKL, which may affect cancer metastasis. In this review we discuss the multifunctional roles of RANKL/RANK in osteoclastogenesis, organogenesis, and the metastasis and tumorigenesis of cancer cells.

Original languageEnglish
Pages (from-to)1609-1622
Number of pages14
JournalFuture Oncology
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2013

Fingerprint

Cell Differentiation
Cell Proliferation
Neoplasm Metastasis
Organogenesis
Neoplasms
Osteogenesis
Bone and Bones
Epithelial-Mesenchymal Transition
Bone Development
Carcinogens
Carcinogenesis
Epithelial Cells
Hormones
Cytokines
Inflammation
Cell Line

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis. / Kukita, Akiko; Kukita, Toshio.

In: Future Oncology, Vol. 9, No. 11, 01.11.2013, p. 1609-1622.

Research output: Contribution to journalReview article

@article{bd99b6feddc6420db5a35e76dd388932,
title = "Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis",
abstract = "It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its receptor RANK. Recent reports demonstrate that RANKL has important roles in organogenesis stimulating proliferation and differentiation of epithelial and stroma cells. RANKL is induced not only by cytokines and hormones but also by UV-irradiation, inflammation and carcinogens. Expression of RANK and RANKL is found in several human cancer cell lines, and RANK signaling stimulates proliferation, migration and epithelial-mesenchymal transition of cancer cells, which may be involved in metastasis via an autocrine/paracrine mechanism. RANKL regulates the number of Tregs that produce RANKL, which may affect cancer metastasis. In this review we discuss the multifunctional roles of RANKL/RANK in osteoclastogenesis, organogenesis, and the metastasis and tumorigenesis of cancer cells.",
author = "Akiko Kukita and Toshio Kukita",
year = "2013",
month = "11",
day = "1",
doi = "10.2217/fon.13.115",
language = "English",
volume = "9",
pages = "1609--1622",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "11",

}

TY - JOUR

T1 - Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis

AU - Kukita, Akiko

AU - Kukita, Toshio

PY - 2013/11/1

Y1 - 2013/11/1

N2 - It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its receptor RANK. Recent reports demonstrate that RANKL has important roles in organogenesis stimulating proliferation and differentiation of epithelial and stroma cells. RANKL is induced not only by cytokines and hormones but also by UV-irradiation, inflammation and carcinogens. Expression of RANK and RANKL is found in several human cancer cell lines, and RANK signaling stimulates proliferation, migration and epithelial-mesenchymal transition of cancer cells, which may be involved in metastasis via an autocrine/paracrine mechanism. RANKL regulates the number of Tregs that produce RANKL, which may affect cancer metastasis. In this review we discuss the multifunctional roles of RANKL/RANK in osteoclastogenesis, organogenesis, and the metastasis and tumorigenesis of cancer cells.

AB - It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its receptor RANK. Recent reports demonstrate that RANKL has important roles in organogenesis stimulating proliferation and differentiation of epithelial and stroma cells. RANKL is induced not only by cytokines and hormones but also by UV-irradiation, inflammation and carcinogens. Expression of RANK and RANKL is found in several human cancer cell lines, and RANK signaling stimulates proliferation, migration and epithelial-mesenchymal transition of cancer cells, which may be involved in metastasis via an autocrine/paracrine mechanism. RANKL regulates the number of Tregs that produce RANKL, which may affect cancer metastasis. In this review we discuss the multifunctional roles of RANKL/RANK in osteoclastogenesis, organogenesis, and the metastasis and tumorigenesis of cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=84887294582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887294582&partnerID=8YFLogxK

U2 - 10.2217/fon.13.115

DO - 10.2217/fon.13.115

M3 - Review article

VL - 9

SP - 1609

EP - 1622

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 11

ER -