Multifunctional silica-based hybrid nanoparticles for biomedical applications

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Multifunctional nanoparticles have contributed to several advances in the biomedical field. For example, many have been shown to provide higher level analysis in fundamental studies on cancer and regenerative medicine. Application of multifunctional nanoparticles as contrast agents or probes for diagnostic imaging enables integration of various imaging modalities which provides greater detail and more accurate information for diagnosis. In addition, these multifunctional materials may help researchers and clinicians combine diagnostics and treatment, called theranostics or image-guided therapy, for minimally invasive treatment of metastatic and minute cancers. Based on the viewpoint of the toxicity and the easily-controlled surface characteristics, shape, and internal function of silica-based hybrid nanoparticles, this review describes that the hybrid nanoparticles break ground for various analytical methods for fundamental studies, diagnostic techniques, and therapies. In particular, the present review focuses on seamless imaging, dual-modal imaging, and image-guided therapy using silica-based multifunctional hybrid nanoparticles with visible and near-infrared fluorescence, as well as X-ray-absorbing, photoresponsive, drug-releasing, and photoinduced heat- and reactive oxygen species-generating capabilities.

Original languageEnglish
Pages (from-to)855-862
Number of pages8
JournalJournal of the Ceramic Society of Japan
Volume124
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Silicon Dioxide
Silica
Nanoparticles
silicon dioxide
nanoparticles
Imaging techniques
therapy
cancer
releasing
medicine
toxicity
Contrast Media
Toxicity
Reactive Oxygen Species
drugs
Fluorescence
Infrared radiation
X rays
heat
fluorescence

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

Cite this

Multifunctional silica-based hybrid nanoparticles for biomedical applications. / Hayashi, Koichiro.

In: Journal of the Ceramic Society of Japan, Vol. 124, No. 9, 01.09.2016, p. 855-862.

Research output: Contribution to journalReview article

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