Multilayer formation of oriented helical peptides glued by hydrogen bonding

Yoshiko Miura, Guo Chun Xu, Shunsaku Kimura, Shiro Kobayashi, Mitsumasa Iwamoto, Yukio Imanishi, Junzo Umemura

Research output: Contribution to journalConference article

13 Citations (Scopus)

Abstract

Hydrophobic helical peptides having nucleotide base analogues were synthesized, and the helix multilayer was formed by interlayer hydrogen bonds to investigate the surface potential of the multilayer. Hydrophobic helical peptides having a diamino-triazine group at the C-terminal were incubated with the thymine-terminated self-assembled monolayer (SAM). The thin layers of helical peptides were formed with a nearly vertical orientation. The amount of peptide adsorbed on the surface increased with increasing concentration of the peptide solution at preparation, indicating multilayer formation. The numbers of helix layers were 10 and 5 for Boc-(Leu-Aib)8-T (T; 4-N-(aminoethyl)amino-2,6-diamino-1,3,5-triazine) and U-Ala-(Leu-Aib)8-T (U; 6-methyluracil), respectively, when 0.4 mM of peptide solution was used for the preparation. The surface potentials of these multilayers were, respectively, 558 mV and 500 mV. The U-Ala-(Leu-Aib)8-T multilayer generated nearly the same surface potential as the Boc-(Leu-Aib)8-T multilayer, even though the membrane thickness was different. The large positive surface potential should promote electron injection from gold to the thin peptide layer, resulting in saturation of the positive potential generation.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalThin Solid Films
Volume393
Issue number1-2
DOIs
Publication statusPublished - Aug 1 2001
Externally publishedYes
Event4th International Conference on Nano-Molecular Electronics - Kobe, Japan
Duration: Dec 5 2000Dec 7 2000

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Miura, Y., Xu, G. C., Kimura, S., Kobayashi, S., Iwamoto, M., Imanishi, Y., & Umemura, J. (2001). Multilayer formation of oriented helical peptides glued by hydrogen bonding. Thin Solid Films, 393(1-2), 59-65. https://doi.org/10.1016/S0040-6090(01)01097-5