Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8

Nobuharu Fujii, Kazuma Ikeda, Naoto Takahashi, Kensuke Kojima, Yoshimi Kobayashi, Atsuko Ashiba, Katsuto Takenaka, Shunnichi Fukuda, Katsuji Shinagawa, Fumihiko Ishimaru, Kenji Niiya, Ikuo Miura, Mitsune Tanimoto, Mine Harada

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Abstract

We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalBritish Journal of Haematology
Volume119
Issue number3
DOIs
Publication statusPublished - Dec 2 2002

All Science Journal Classification (ASJC) codes

  • Hematology

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    Fujii, N., Ikeda, K., Takahashi, N., Kojima, K., Kobayashi, Y., Ashiba, A., Takenaka, K., Fukuda, S., Shinagawa, K., Ishimaru, F., Niiya, K., Miura, I., Tanimoto, M., & Harada, M. (2002). Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8. British Journal of Haematology, 119(3), 716-719. https://doi.org/10.1046/j.1365-2141.2002.03922.x