Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

Koji Shinoda, Hideaki Asahara, Taira Uehara, Katsue Miyoshi, Satoshi O. Suzuki, Toru Iwaki, Jun Ichi Kira

Research output: Contribution to journalLetter

3 Citations (Scopus)

Abstract

We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

Original languageEnglish
Pages (from-to)252-254
Number of pages3
JournalMultiple Sclerosis Journal
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 17 2015

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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