Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia - Report of a case

Yosuke Adachi, Masaki Mori, Akinori Kido, Reishi Shimono, Taketoshi Suehiro, Keizo Sugimachi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We report on a 22-year-old man with congenital hypogammaglobulinemia who developed multiple colorectal neoplasms. An immunodeficiency had been diagnosed in the patient since two years of age, and this time many tumors of the sigmoid colon and rectum were detected by barium enema and fiberscopy. Abdominoperineal resection was performed, and the resected specimen revealed 29 polyps, including 9 adenocarcinomas and 20 adenomas. The carcinomas, measuring 0.8 to 11.0 cm in size, showed various depths of invasion, and the adenomas, measuring 0.2 to 1.5 cm in size, showed various degrees of epithelial atypia. DNA analysis demonstrated that the tumors were heterogeneous, showing different DNA index and ploidy patterns. The pathogenetic relation between malignancy and immunodeficiency is also reviewed.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalDiseases of the Colon & Rectum
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 1 1992

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Agammaglobulinemia
Young Adult
Colorectal Neoplasms
Adenoma
Neoplasms
Ploidies
DNA
Sigmoid Colon
Polyps
Rectum
Adenocarcinoma
Carcinoma

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia - Report of a case. / Adachi, Yosuke; Mori, Masaki; Kido, Akinori; Shimono, Reishi; Suehiro, Taketoshi; Sugimachi, Keizo.

In: Diseases of the Colon & Rectum, Vol. 35, No. 2, 01.02.1992, p. 197-200.

Research output: Contribution to journalArticle

Adachi, Yosuke ; Mori, Masaki ; Kido, Akinori ; Shimono, Reishi ; Suehiro, Taketoshi ; Sugimachi, Keizo. / Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia - Report of a case. In: Diseases of the Colon & Rectum. 1992 ; Vol. 35, No. 2. pp. 197-200.
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