Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development

Ken ichi Hironaka, Yoh Iwasa, Yoshihiro Morishita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Organ morphogenesis starts with the spatial patterning of different gene expressions in organ primordia, which is based on positional information provided by morphogens. To generate precise positional information, the robust localization of morphogen sources is needed. This can be realized by several different mechanisms, such as (i) by reducing the variations in spatial arrangement of morphogen sources, (ii) by reducing the variations in their source levels, and (iii) by increasing the degree of source localization with the sharp boundary that makes morphogen gradients steeper. Here we focus on the mechanism of localization of wingless expression, one of the important morphogens in Drosophila notum development. The mechanism of wingless-localization can be explained by a simple feed-forward loop network motif, but the real molecular network adopted by the organism is much more complex; it includes multiple feedback loops that function with the feed-forward loop in a coordinated manner. To clarify the functions of the molecular network, we decompose it into three sub-modules, each of which includes a single feedback loop, and examine their possible roles using a mathematical model. We demonstrate how the regulatory network for wingless expression realizes the conditions (i)-(iii) for its robust localization.

Original languageEnglish
Pages (from-to)18-29
Number of pages12
JournalJournal of Theoretical Biology
Volume292
DOIs
Publication statusPublished - Jan 7 2012

Fingerprint

Drosophilidae
Feedback Loop
Drosophila
Feedback
Feedforward
Morphogenesis
Gene expression
morphogenesis
spatial variation
Theoretical Models
mathematical models
Mathematical models
Gene Expression
Source Localization
gene expression
Regulatory Networks
organisms
Patterning
Arrangement
Mathematical Model

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development. / Hironaka, Ken ichi; Iwasa, Yoh; Morishita, Yoshihiro.

In: Journal of Theoretical Biology, Vol. 292, 07.01.2012, p. 18-29.

Research output: Contribution to journalArticle

Hironaka, Ken ichi ; Iwasa, Yoh ; Morishita, Yoshihiro. / Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development. In: Journal of Theoretical Biology. 2012 ; Vol. 292. pp. 18-29.
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