Multiple focal cortical dysplasias presenting with intractable epilepsy: Case report

K. Fukui, T. Morioka, S. Nishio, T. Kawamura, C. M. Wu, T. Uesaka, T. Yoshiura, M. Sasaki

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Abstract

A 14-year-old female, who had intractable epilepsy associated with multiple focal cortical dysplasias (FCD), was reported. She developed intractable epilepsy at the age of 7 and was diagnosed as having frontal lobe epilepsy based on the seizure semiology and interictal EEG. MRI revealed multiple lesions in the right frontal, bilateral occipital and left parietal lobes. EEG demonstrated that ictal discharge was preceded by spike on the right frontal region and FDG-PET showed hypometabolic area in the right frontal lobe. Chronic subdural electrode recordings from the right frontal lobe indicated that ictal onset zone was located around the right frontal lesion, especially frontal tip and base, and these areas including the lesion were resected. Postoperatively, residual seizure was noted although seizure frequency was decreased. It is well known that, postoperatively, satisfactory seizure outcome can be obtained in patients with FCD. However, further investigation in terms of surgical indication and strategies for multiple FCD should be needed.

Original languageEnglish
Pages (from-to)961-967
Number of pages7
JournalBrain and Nerve
Volume53
Issue number10
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Fukui, K., Morioka, T., Nishio, S., Kawamura, T., Wu, C. M., Uesaka, T., Yoshiura, T., & Sasaki, M. (2001). Multiple focal cortical dysplasias presenting with intractable epilepsy: Case report. Brain and Nerve, 53(10), 961-967.