Multiple intracranial recurrent tumors with hyperprolactinemia combined with a parasellar malignant fibrous histiocytoma long after transfrontal surgery and irradiation to a pituitary adenoma

M. Fujikawa, K. Okamura, K. Sato, M. Shiratsuchi, T. Yao, T. Mizokami, M. Fujishima

Research output: Contribution to journalArticle

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Abstract

We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadenoma. One recurrent tumor was in the right orbital apex causing right oculomotor nerve palsy, and the other tumor was in the right apex partispetrosae and foramen jugulare. Although her serum prolactin level decreased after the administration of bromocriptine mesilate, and the size of the two tumors remained unchanged, a malignant fibrous histiocytoma, which might have been induced by the irradiation 18 years before, grew rapidly in the right suprasellar-prepontine cistern to the right pedunculus cerebralis, leading to a poor prognosis. This case confirmed the importance of the life-lasting follow-up of pituitary adenomas treated with surgery and/or irradiation therapy. Not only ectopic recurrence of the primary tumor but also post-irradiation tumors may become apparent long after the removal of the primary tumor.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalJournal of Endocrinological Investigation
Volume24
Issue number6
DOIs
Publication statusPublished - Jan 1 2001

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Malignant Fibrous Histiocytoma
Hyperprolactinemia
Pituitary Neoplasms
Neoplasms
Prolactin
Oculomotor Nerve Diseases
Mesylates
Bromocriptine
Craniotomy
Recurrence
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Multiple intracranial recurrent tumors with hyperprolactinemia combined with a parasellar malignant fibrous histiocytoma long after transfrontal surgery and irradiation to a pituitary adenoma. / Fujikawa, M.; Okamura, K.; Sato, K.; Shiratsuchi, M.; Yao, T.; Mizokami, T.; Fujishima, M.

In: Journal of Endocrinological Investigation, Vol. 24, No. 6, 01.01.2001, p. 448-453.

Research output: Contribution to journalArticle

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AU - Yao, T.

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AU - Fujishima, M.

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