Multiple mechanisms for p27Kip1 translocation and degradation

Etsuo Susaki, Keiichi I. Nakayama

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.

Original languageEnglish
Pages (from-to)3015-3020
Number of pages6
JournalCell Cycle
Volume6
Issue number24
DOIs
Publication statusPublished - Dec 15 2007

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Cyclin D2
Cell Nucleus Active Transport
Cyclin-Dependent Kinases
Growth
Cell Cycle

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Multiple mechanisms for p27Kip1 translocation and degradation. / Susaki, Etsuo; Nakayama, Keiichi I.

In: Cell Cycle, Vol. 6, No. 24, 15.12.2007, p. 3015-3020.

Research output: Contribution to journalReview article

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