Abstract
The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.
| Original language | English |
|---|---|
| Pages (from-to) | 3015-3020 |
| Number of pages | 6 |
| Journal | Cell Cycle |
| Volume | 6 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 15 2007 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology
- Cell Biology
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Multiple mechanisms for p27Kip1 translocation and degradation. / Susaki, Etsuo; Nakayama, Keiichi I.
In: Cell Cycle, Vol. 6, No. 24, 15.12.2007, p. 3015-3020.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Multiple mechanisms for p27Kip1 translocation and degradation
AU - Susaki, Etsuo
AU - Nakayama, Keiichi I.
PY - 2007/12/15
Y1 - 2007/12/15
N2 - The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.
AB - The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.
UR - http://www.scopus.com/inward/record.url?scp=38149033464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38149033464&partnerID=8YFLogxK
U2 - 10.4161/cc.6.24.5087
DO - 10.4161/cc.6.24.5087
M3 - Review article
C2 - 18075313
AN - SCOPUS:38149033464
VL - 6
SP - 3015
EP - 3020
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 24
ER -