Multiple sclerosis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Longitudinally extensive spinal cord lesions that extend over three vertebral segments on magnetic resonance imaging (MRI) are significantly more common in opticospinal multiple sclerosis (OSMS) than in conventional MS (CMS) in Japanese. In Japanese patients with MS, concentrations of serum vascular endothelial growth factor (VEGF) were significantly higher in MS patients in relapse than in controls or MS patients in remission, irrespective of clinical subtype. VEGF at relapse showed a significant positive correlation with the length of the spinal cord lesions on MRI. The IL-17/IL-8 system in cerebrospinal fluid (CSF) was markedly activated in OSMS, and both cytokines correlated with CSF/serum albumin ratio and the spinal cord lesion length on MRI. IL-17 is produced by autoreactive memory T cells and induces IL-8 production in a variety of cells. IL-8 acts as a chemokine for neutrophils as well as T cells. In autopsied spinal cords from OSMS patients, many neutrophils were seen to infiltrate the severely damaged spinal cord lesions; something that might be explained by intrathecal activation of IL-17/IL-8 axis in this condition. Our results, therefore, suggest that an increase in both serum VEGF and CSF IL-17 and IL-8 might contribute to the formation of longitudinally extensive spinal cord lesions through an increase of vascular permeability and the reinforcement of neutrophilic inflammation.

Original languageEnglish
Pages (from-to)912-915
Number of pages4
JournalClinical Neurology
Volume45
Issue number11
Publication statusPublished - Nov 2005

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Multiple Sclerosis
Spinal Cord
Interleukin-8
Interleukin-17
Vascular Endothelial Growth Factor A
Cerebrospinal Fluid
Magnetic Resonance Imaging
Neutrophils
T-Lymphocytes
Recurrence
Capillary Permeability
Serum
Chemokines
Serum Albumin
Cytokines
Inflammation
Opticospinal Multiple Sclerosis

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Multiple sclerosis. / Kira, Jun-Ichi.

In: Clinical Neurology, Vol. 45, No. 11, 11.2005, p. 912-915.

Research output: Contribution to journalArticle

Kira, J-I 2005, 'Multiple sclerosis', Clinical Neurology, vol. 45, no. 11, pp. 912-915.
Kira J-I. Multiple sclerosis. Clinical Neurology. 2005 Nov;45(11):912-915.
Kira, Jun-Ichi. / Multiple sclerosis. In: Clinical Neurology. 2005 ; Vol. 45, No. 11. pp. 912-915.
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