Multiple sclerosis in the Japanese population

Research output: Contribution to journalReview article

350 Citations (Scopus)

Abstract

Multiple sclerosis (MS) in Asian populations is characterised by the selective and severe involvement of the optic nerve and spinal cord as well as low prevalence rates. 15-40% of cases of MS in Japan are of this "opticospinal" type. This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501. In Japanese people born after modernisation in the 1960s, the ratio of conventional to opticospinal MS has increased rapidly. Opticospinal MS is likely to have a distinct immune-mediated mechanism, which is not operative in conventional MS.

Original languageEnglish
Pages (from-to)117-127
Number of pages11
JournalLancet Neurology
Volume2
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

Fingerprint

Multiple Sclerosis
Population
Spinal Cord
Oligoclonal Bands
HLA-DRB1 Chains
Recurrence
Leukocytosis
Optic Nerve
Social Change
Age of Onset
Japan
Opticospinal Multiple Sclerosis
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Multiple sclerosis in the Japanese population. / Kira, Jun Ichi.

In: Lancet Neurology, Vol. 2, No. 2, 01.02.2003, p. 117-127.

Research output: Contribution to journalReview article

@article{e61a67e2647543b490cc39269bf65242,
title = "Multiple sclerosis in the Japanese population",
abstract = "Multiple sclerosis (MS) in Asian populations is characterised by the selective and severe involvement of the optic nerve and spinal cord as well as low prevalence rates. 15-40{\%} of cases of MS in Japan are of this {"}opticospinal{"} type. This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501. In Japanese people born after modernisation in the 1960s, the ratio of conventional to opticospinal MS has increased rapidly. Opticospinal MS is likely to have a distinct immune-mediated mechanism, which is not operative in conventional MS.",
author = "Kira, {Jun Ichi}",
year = "2003",
month = "2",
day = "1",
doi = "10.1016/S1474-4422(03)00308-9",
language = "English",
volume = "2",
pages = "117--127",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "Lancet Publishing Group",
number = "2",

}

TY - JOUR

T1 - Multiple sclerosis in the Japanese population

AU - Kira, Jun Ichi

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Multiple sclerosis (MS) in Asian populations is characterised by the selective and severe involvement of the optic nerve and spinal cord as well as low prevalence rates. 15-40% of cases of MS in Japan are of this "opticospinal" type. This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501. In Japanese people born after modernisation in the 1960s, the ratio of conventional to opticospinal MS has increased rapidly. Opticospinal MS is likely to have a distinct immune-mediated mechanism, which is not operative in conventional MS.

AB - Multiple sclerosis (MS) in Asian populations is characterised by the selective and severe involvement of the optic nerve and spinal cord as well as low prevalence rates. 15-40% of cases of MS in Japan are of this "opticospinal" type. This form of MS generally has a higher age at onset and a higher female to male ratio than conventional MS. Opticospinal MS is also characterised by frequent relapses, severe disability, few brain lesions visible on MRI, long lesions extending over many vertebral segments visible on spinal-cord MRI, pleocytosis and an absence of oligoclonal bands in the CSF, and a pronounced shift in the responses of T-helper-1 and T-cytotoxic-1 cells throughout relapse and remission phases. Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501. In Japanese people born after modernisation in the 1960s, the ratio of conventional to opticospinal MS has increased rapidly. Opticospinal MS is likely to have a distinct immune-mediated mechanism, which is not operative in conventional MS.

UR - http://www.scopus.com/inward/record.url?scp=0042512328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042512328&partnerID=8YFLogxK

U2 - 10.1016/S1474-4422(03)00308-9

DO - 10.1016/S1474-4422(03)00308-9

M3 - Review article

C2 - 12849268

AN - SCOPUS:0042512328

VL - 2

SP - 117

EP - 127

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 2

ER -