Abstract
In this review, we summarized the recent progress of research and treatment of multiple sclerosis (MS). The immunogenetic study including analyses of HLA polymorphism revealed that there are two distinct subtypes of MS: Asian-type and Western-type. Since MS is a polygenic disease, there must be several susceptible genes other than HLA. A large number of candidate genes are being searched and analyzed for polymorphism. Autoantigens responsible for MS are of great interest. Screening peptide library which bind to MS susceptible genes are expected to provide with new autoantigens. Advance in treatment is also remarkable. Since interferon (IFN)-beta 1b became available, great deal of data concerning IFN beta are accumulated. IFN beta not only reduced clinical exacerbation and MRI brain lesions but also slowed the development of brain atrophy. New treatments include altered peptide ligand therapy and oral tolerization with myelin antigens, which are on the clinical trial. Vaccination with myelin reactive T cells or T cell receptor peptide also attracts a great deal of attention.
| Original language | English |
|---|---|
| Pages (from-to) | 1211-1218 |
| Number of pages | 8 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 59 |
| Issue number | 6 |
| Publication status | Published - Jan 1 2001 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Multiple sclerosis : the recent progress of research and treatment. / Murai, Hiroyuki; Kira, Jun-Ichi.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 59, No. 6, 01.01.2001, p. 1211-1218.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Multiple sclerosis
T2 - the recent progress of research and treatment
AU - Murai, Hiroyuki
AU - Kira, Jun-Ichi
PY - 2001/1/1
Y1 - 2001/1/1
N2 - In this review, we summarized the recent progress of research and treatment of multiple sclerosis (MS). The immunogenetic study including analyses of HLA polymorphism revealed that there are two distinct subtypes of MS: Asian-type and Western-type. Since MS is a polygenic disease, there must be several susceptible genes other than HLA. A large number of candidate genes are being searched and analyzed for polymorphism. Autoantigens responsible for MS are of great interest. Screening peptide library which bind to MS susceptible genes are expected to provide with new autoantigens. Advance in treatment is also remarkable. Since interferon (IFN)-beta 1b became available, great deal of data concerning IFN beta are accumulated. IFN beta not only reduced clinical exacerbation and MRI brain lesions but also slowed the development of brain atrophy. New treatments include altered peptide ligand therapy and oral tolerization with myelin antigens, which are on the clinical trial. Vaccination with myelin reactive T cells or T cell receptor peptide also attracts a great deal of attention.
AB - In this review, we summarized the recent progress of research and treatment of multiple sclerosis (MS). The immunogenetic study including analyses of HLA polymorphism revealed that there are two distinct subtypes of MS: Asian-type and Western-type. Since MS is a polygenic disease, there must be several susceptible genes other than HLA. A large number of candidate genes are being searched and analyzed for polymorphism. Autoantigens responsible for MS are of great interest. Screening peptide library which bind to MS susceptible genes are expected to provide with new autoantigens. Advance in treatment is also remarkable. Since interferon (IFN)-beta 1b became available, great deal of data concerning IFN beta are accumulated. IFN beta not only reduced clinical exacerbation and MRI brain lesions but also slowed the development of brain atrophy. New treatments include altered peptide ligand therapy and oral tolerization with myelin antigens, which are on the clinical trial. Vaccination with myelin reactive T cells or T cell receptor peptide also attracts a great deal of attention.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035380637&partnerID=8YFLogxK
M3 - Review article
VL - 59
SP - 1211
EP - 1218
JO - Astrophysical Journal
JF - Astrophysical Journal
SN - 0004-637X
IS - 6
ER -